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DEEPTHY DAMIEN
01/21/2010
Chief Complaint
4
prior hospitalizations
Seen in the Ortho clinic for intoeing
Surgical
history : none
Medications: none
Allergies: none
Family History: none
Birth history: normal delivery ,no complications
Social history: Lives with parents and brother
Immunizations: up to date
ROS
HEENT:No
headache /congestion/epistaxis
Resp: No cough /wheeze
Cardiac: No chest pain /cyanosis/palpitation
Abdomen: No abd pain/diarrhea/constipation
GU:neg
Skin:pos for bruising
Neuro:No weakness/seizure
Physical Exam
Labs
CBC:6.7/12.9/34.6/7
P/S:
Diagnosis
Orders at Admission
CBC
with diff
CMP,Uric acid,LDH,ESR,PS
PT/INR/PTT
NO NSAIDS
NO STEROIDS
Monitor for bleeding
Restrict activities
DAY 2
Patient stable
No new lesions/ bleeding
LABS:
CBC:6.7/12.9/36.8/5
ESR:7
CRP: 0.3
PT:11.8/INR:1.1/PTT:26.6
CMP:142/3.5/104/27/11/0.5
ALP:170/AST:32/ALT:20/Bili:0.1
LDH:618
Uric acid:4.3
Orders
IV
IG 1 g /Kg IV x1
DAY 3
Patient
stable
No new lesions
CBC:4.1/1.6/36.5/46
Discharged home with ,advised to f/u with
PCP in 1 wk,CBC prior to clinic visit
Pathogenesis
Auto
Epidemiology
ITP
Clinical Presentation
History:
Physical Findings:
Disease course: 70% of children have the acute form of ITP, which is
Diagnosis:2 criteria
Labs:
CBC:
thrombocytopenia , usually the only abnormality detected,usually <20,000/microL
Peripheral smear:
no morphologic abnormalities in WBC/RBC.Platelet decreased in number,often large in
size.
Other studies :
Coags,coombs test,retic count,HIV,studies for collagen vascular/rheumatoid disorders.
Anti platelet ab testing-not routinely indicated in kids
Bone marrow exam:
increase number of megakaryocytes,may appear large and immature
Routinely performed in the past to r/o marrow failure or malignancy(acute
lymphoblastic leukemia).New guidelines BM exam is unnecessary in the typical
case of childhood ITP
Indication
for BM exam:
-Atypical presentation
-Persistent thrombocytopenia beyond 6 months
-subsequent clinical course that is not consistent
with ITP
- Before Steroid treatment in typical ITP is
recommended by some .(not by UpToDate)
Differential Diagnosis
Viral infection(IMN,Hepatitis,HIV- 1)
Drug exposure(Heparin, Quinidine, Sulfonamide)
Autoimmune Disorders(SLE)
Leukemia (ALL)
Acquired marrow failure syndrome (aplastic anemia)
Inherited thrombocytopenic
disorders(thrombocytopenia-absent radius syndrome,
Wiskott-Aldrich syndrome,mutation of MYH 9 gene)
Treatment
Initial
medical management:
-Ideal management still unclear -observation
alone vs observation with pharmacologic
intervention
-restrict contact sports/physical activity
-avoid medications with antiplatelet or
anticoagulant activities
Pharmacologic Intervention
Presence of severe life threatening bleeding,risk of significant bleeding
(going for procedures/count <10,000/microL and cutaneous bleeding),
concomitant / preexisting conditions(hemophilia) need intervention
Corticosteroids:
Reduce Ab production,RES phagocytosis of antibody coated
platelets,improve vascular integrity, improve platelet production
Prednisone 1-2 mg/kg/day(max 60 /day) in 3 divided doses x 2-4 wks,
followed by a taper of 4mg / kg/day ,divided into 3 doses for 4 days
OR
Methylprednisolone( 30-50 mg /kg/day) for 3-7 days
Some cases may need repeat courses
IV IG:
Mechanism of action is multi-factorial,inhibition of
antibody adsorption to platelets,prevention of RES
uptake of auto ab coated platelets, interaction of auto
abs with idiotype abs in IV IG.
Works better than steroids but higher cost
Dose:
400mg /kg/day x 5 days
OR
Single dose of 1g/kg
Bibliography
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