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2 liters/day urine
Maintains balance:
Water : Salts
Acids : Bases
Renin regulates BP
Activation of vitamin D
Figure 25.1a
Figure 25.2a
Internal Anatomy
9. Peritubular
capillaries, vasa recta
7. glomerulus
8. Efferent arteriole
6. Afferent arteriole
10.
5.
11.
4.
12.
3.
2.
1.
13.
Figure 25.3b
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InterActive Physiology :
Anatomy Review, page 5
Figure 25.3c
Internal Anatomy
9. Peritubular
capillaries/ Vasa recta
7. glomerulus
8. Efferent arteriole
6. Afferent arteriole
10.
5.
11.
4.
12.
3.
2.
1.
13.
Figure 25.3b
The Nephron
The Nephron
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InterActive Physiology :
Urinary: Anatomy Review, pages 7-9
The Nephron
Thick loop, Ascending loop- cuboidal, short
microvilli; permeable to solutes, esp NaCl, not to
water
1.
Figure 25.4a, b
2 Cell Types
1. Intercalated cells
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Anatomy Review, pages 1215, 1719
Nephrons- 2 Types
1. Cortical nephrons- Bowmans capsule in cortex
Concentrate urine
Capillary Beds
Figure 25.5a
Glomerulus
Glomerulus BP is high:
Capillary Beds
Peritubular beds:
Concentrate urine
Nephron Anatomy
Figure 25.5a
Secrete renin
Mechanoreceptors
Mesanglial cells:
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Anatomy Review: page 16
JG cells or
Figure 25.6
Filtration Membrane
Three layers
2.
1.
3. Fused basement
membrane between other 2
layers
Figure 25.7a
Filtration Membrane
PLAY
Figure 25.7c
Filtrate:
Urine:
Figure 25.8
Glomerular Filtration
Figure 25.9
Factors:
1. Total surface area available for filtration
2. Filtration membrane permeability
3. Net filtration pressure
Autoregulation:
Myogenic
Everything is reabsorbed
angiotensin I
angiotensin II
1. > BP (vasoconstriction)
2. Aldosterone release (> Na++, > H20, >BP)
3. ADH release, thirst activation, > H20, > BP
4. Constriction of efferent arteriole, < peritubular capillary
hydrostatic pressure, > fluid back in blood, > BP
5. Mesangial cells contract, < GFR
ANP- by heart with > BP, > blood volume; < fluid
volume by > Na+ secretion
Regulation of GFR
Figure 25.10