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CASE STUDY
Hala Kilany, MD.
CASE-1
A patient with diarrhea:
-pH=7.23
-HCO3-=10meq\l
-PCO2=23 mmHg
CASE-2
A 51 year-old man passes out while waiting in the
Emergency department. He is noted to have no pulse
and cardiopulmonary resuscitation is begun. Initial
laboratory data show:
Arterial pH = 7.30
Arterial PCO2 = 30 mmHg
Plasma sodium = 140 meq/L
Plasma potassium = 4.1 meq/L
Plasma chloride = 100 meq/L
Plasma bicarbonate = 15 meq/L
A. What is the acid-base disorder?
B. Calculate the anion gap?
C. What is the most likely diagnosis?
CASE-3
A 23 year-old man with no prior history
complains of polyuria, polydipsia, and
polyphagia for 2 weeks. He also notes
some shortness of breath. The physical
examination reveals a blood pressure
of 120/80 supine, 90/60 standing,
increased respiratory rate, and
decreased skin turgor. The initial
laboratory data reveal:
Plasma
Plasma
Plasma
Plasma
CASE-4
A 1 year-old child was seen by his pediatrician for
a routine evaluation and was found to weigh 10
kg. Two days later, he is seen in the Emergency
Department for diarrhea and dehydration. At this
time, the physical examination reveals:
-a pulse of 140, respiratory rate 32/min,
-blood pressure 90/, and weight
8.9 kg. He appears moderately dehydrated with
dry mucous membranes and no tears when he
cried. There are no other significant
abnormalities. Laboratory data on admission
reveal:
Na+\Cl-=138\104=1.32: hyperchloremic
metabolic acidosis.
AG=23 high AG metabolic acidosis
Hco3-=24-11=13,PCO2 drop should be:
1.2x13=15.6 almost 24
So, it is a combined condition of:
-high AG metabolic acidosis, probably due to
lactic acidosis secondary to the severe
diarrhea.
-hyperchloremic metabolic acidosis, due to
diarrhea.
CASE-5
A 31 year-old man with a history of
epilepsy has a grand mal seizure.
Laboratory tests taken immediately after
the seizure has stopped reveal:
-pH=7.14
-PCO2=45mmHg
-plasma [Na+]=140meq\l
-[K+]=4meq\l
-[Cl-]=98meq\l
-[HCO3-]=17meq\l
This is a combined:
-high AG metabolic acidosis: AG= 25
-respiratory acidosis, C02 is much
higher than expected.
Usually, for nephrologists the value of
a pH=7.2, is a requirement for
treating the acidosis, some references
and studies done by ICU specialist go
below that, to a value of pH=7.1.
HYPONATREMIA CASES
Case-1:A 56 year-old man presents to the
doctor for the first time complaining of fatigue
and weight loss. He has never had any health
problems, but he has smoked a pack of
cigarettes per day for about 35 years. He is a
day laborer and is currently homeless and
living in a shelter. His physical examination is
notable for a low to normal blood pressure,
skin hyperpigmentation, and digital clubbing.
He appears euvolemic. You do some blood
tests, and it showed the following:
Lab tests
Na+=126meq/l
K+=6,7meq/l
Chloride and bicarbonate are low.
Creatinine normal.
What is your diagnosis?
A-SIADH
B-hypothyroidism
C-GI losses
D-Adrenal insufficiency
E-Renal insufficiency