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α1 (vasoconstriction)
0.2-1 mcg/kg/min
expect a reflexive drop in HR
isoproterenol
“chemical pacemaker”
inodilator
inotropy to heart
pulmonary vasodilator
phosphodiesterase inhibitor
thus breakdown of cAMP leads to cycling of Ca2+ from SR during
excitation/coupling of heart muscle
Load: 50-75 mcg/kg over 10 minutes
Infuse: 0.375-0.75 mcg/kg/min
long ½ life = difficult to titrate = miles and miles of milrinone
uses: CHF, pulm HTN, RV dysfunction
dopamine
“dopam1ne – the interns drip”
α1 (vasoconstriction)
β1 (ino & chron0)
DA1 (dilation & diuresis)
2-10 mcg/kg/min
“renal dosing dogma” – small doses thought to
produce renal vasodilation due to DA1 receptor
norepinephrine (Levophed)
“leave em dead with ischemic digits”
α1 (vasoconstriction)
β1 (ino & chron0)
0.02 – 0.3 mcg/kg/min
can be seen as an “end of the effort” drip
powerful squeeze leave fingers and toes black/necrotic
from ischemia
Epinephrine
“live people hate it, dead people love it”