Review article

Systematic review
Meta analysis

Integrative Literature

Bastian, Glasziou, Chalmers (2010) 75 Trials and 11Systematic Reviews a Day: How Will We Ever Keep Up? PLoS Med 7(9)

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Streptokinase for Myocardial Infarction

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IDENTIFIKASI

SELEKSI

ABSTRAKSI

METODOLOGI
PENELITIAN

MEMINIMALKAN
ERROR & BIAS

ANALISA
LANGKAH-LANGKAH DALAM MELAKUKAN META ANALISA ( Okin, 1996 )

Potentially relevant
RCTs (n= ..)
n RCTs excluded with reason
RCTs retrieved for more
detailed information (n= ..)
n RCTs excluded with reason
Potentially appropriate
RCTs (n= ..)
n RCTs excluded with reason
RCTs in meta-analysis (n=..)

Meta-analysis of RCTs with nominal outcome

Study I
Study II
Study III
Study IV
Study V
Study VI
Study VII1
Study VIII

1992
1994
1995
1995
1996
1997
1999
2000

Combined
0.1

Favor drug

10

OR = 1

Favor placebo

Meta-analysis of RCTs, numerical outcome

Study I 1992
Study II 1994
Study III 1995
Study IV 1995
Study V 1996
Study VI 1997
Study VII1999
Study VIII 2000
Combined
-0.3

+0.3

Xe-xc=0
Favor drug

Favor placebo

FOREST PLOT

The label tells you what the comparison and outcome

of interest are

FOREST PLOT
Each study has an ID

FOREST PLOT
The data for each trial are here, divided into
experimental and control groups

FOREST PLOT
This is the % weight given to each study in the pooled analysis

FOREST PLOT
Results from each trial are also given numerically

FOREST PLOT
The size of the block for each study is proportional to the % weight.
The horizontal line represents the confidence interval.

FOREST PLOT
The label above the graph tells you which statistic has been used

FOREST PLOT
Take care to read the labels
things to the left do not always mean the treatment
is better than the control

FOREST PLOT
The pooled analysis is given a diamond shape
The widest bit is located on the point estimate
and the horizontal width in the confidence interval.
Does the confidence interval cross the line of no effect?

FOREST PLOT
Results of the pooled analysis are also given numerically

FOREST PLOT
Test for heterogeneity
The result of a Z test with a p value are also given
for the overall effect