Académique Documents
Professionnel Documents
Culture Documents
2.
Emily Cribas
Albert Einstein
July 7, 2015
College of Medicine,
NY
SSRP Journal Club
Harvard Medical
School
3. Ludwig Institute for
Cancer Research
Colon Cancer
Colon cancer
2nd leading cause
of cancer-related
death
Factors increase
risk
Diet
The colon
Absorbs vitamins
Stores and
eliminates waste
Breaks down
non-digestible
foods
http://www.csiro.au/hungrymicrobiome/
http://www.csiro.au/hungrymicrobiome/
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
Conclusions
KLF5 is a key regulator of butyrate
induction of ALPi in colon cancer cells
40
Critique
Redundant
Methods were a little unclear
Couldve used newer methods
41
Future Work
Explore other transcriptional factors
that might play a role in ALPi
expression
Test relationship between butyrate
and differentiation phenotype
Look genome-wide
42
43