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Trilaminar germ disc


Dr Manah Chandra Changmai M

Formation of embryonic mesoderm and endoderm
Primitive streak on the surface of the epiblast
The cephalic end of the streak,known as primitive node
Primitive node surrounds the a small primitive pit

Primitive streak
Day 14 -15 raised groove appears
on dorsal surface of the epiblast
cells migrate inward at the streak,
displacing underlying hypoblast to
become the endoderm
Day 16 ingressing epiblast cells
form the mesoderm (a new layer
between the epiblast and
Epiblast cells that remain on the
embryos dorsal surface make up
the ectoderm
Ectoderm & endoderm = epithelia
Mesoderm = mesenchyme tissue
(mesen=middle; chyme=fluid)

Formation of notochord
Cells invaginating the primitive pit Move straight
forward in cephalic direction upto prochordal plate.
Form a tube like process known as notochordal or
head process.
By the 18th day,floor of the
notochordal process fuses with
underlying endoderm
Lumen of the notochordal
process disappears completely
Notocordal process forms a
narrow plate of cells
Notochordal cells proliferate
and forms solid cord,known as
definitive notochord.

Formation of cloacal membrane

Cloacal membrane is formed caudal to primitive streak,

consists of tightly adherent ectoderm and endoderm.
At 16th day a diverticulum is formed at the posterior wall
of yolk sac which extends into connecting
This diverticulum is called allantoenteric diverticulum or
In humans it remains rudimentary.

Changes in embryonic disc

Embryonic disc,initially flat and almost round
Later becomes elongated with broad cephalic
and narrow caudal end.
At the end of 4th week primitive streak shows
regressive changes and soon disappears.
Sometimes remnants of primitive streak persists
persists and at birth cause tumours of sacrococcygeal

Further development of tropoblast

After 3rd week mesodermal cells

penetrate the core of primary villi
forming secondary villi.
At the end of 3rd week mesodermal cells
in the core of villi differentiate into blood
cells forming tertiary villus.

Tertiary villi

Further development of tropoblast.

Cytotropoblastic cell penetrate into

the syncytium until they reach the
maternal endometrium
Establish contact with similar neighbouring
villous stems forming thin outer cytotropoblastic
Villi that extend from chorionic plate form decidua
basalis called the stem or anchoring villi.
Chorionic cavity becomes larger by 19th or 20th
Embryo is attached to tropoblastic
shell by connecting stalk

The end