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20140511
Introduction
2. Specific brain regions & anatomical connections: complex & diverse response, l
evel hierarchy, confluence zones
Introduction
Arrangement: topology
Identifies network elements having strong influence on the global network functio
n
Hub Detection
Network hub: nodes that make strong contributions to global network function
Detected by
3. Closeness centrality: average distance btw a given node and the rest of the netw
ork
Hub Detection
Network community(=module): nodes more densely linked among each other than wit
h nodes in other communities
Rich club: collectives of high-degree nodes and their interconnecting edges facilitate
mutual interactions
Structural core: recursive pruning of nodes of increasing degree resilient nodes (den
sely interconnected)
Structural Network
Functional Network
Structural Hubs
Their Integrative & diversive properties central embedding within connection top
ology
Structural Hubs
2. metabolic active
Shaped by trade-offs btw wiring cost, spatial &metabolic constraint & efficiency
Functional Hubs
Functional Hubs
Other approach: examine participation across multiple functional networks & level of overl
ap btw different functional domain
Primary regions (primary motor, visual & auditory): single or small # of functional networks
Putative hub regions (medial superior frontal, anterior cingulate, precuneus/posterior cing
ulate gyrus): multiple functional networks
Flexible network hubs: capacity to link & interact w/ diverse brain regions adaptively (+time
& temporal variability)
Identification depends on
Genetic influence
Structural hubs emerge early, but functionally immature, confined to primary visual
& motor
Hub regions remain relatively stable; their interaction undergo developmental chan
ges
Sex-related difference in hormone (eg. LH) level affect white matter brain connect
ivity
Autism: altered intra- & intermodular connectivity of densely connected limbic, tem
poral & frontal regions
Cognitive decline associated with white matter damage & network integrity
Neural hubs derive their influence from their strong participation in dynamic interactio
ns due to neuronal signaling
Infer communication patterns focusing on layout of short paths & centrality of nodes (r
elative to these paths)
Structural & functional hubs play a central role in global brain communication
Hub regions may also render them potential neural bottlenecks of information flow: s
et upper bounds for integration, chaining & serializing mental operations
Limitations intrinsic to network models; reflect our ignorance & lack of data
some nodes may preferentially engage in neural communication; others rarely or never
3. assume nodes connect along most efficient paths, are accessible, dominant criterion
Require detailed studies that track actual network paths of information flow
Some cortical hub regions maintain an unequal balance of incoming and outgoing
projections
Hub Connections
Strong hub connections (in white matter): structural modules & functional restingstate networks vulnerability
Brain hubs & their connections: convergent structure for integration of informatio
n, forming putative substrate for functional global workspace
cognitive architecture in which segregated functional systems can share & integr
ate information neuronal interactions
Central hub nodes engage on more variable or noisy dynamics structural rewiring
Highly connected hub nodes & connections dominate systems dynamical organizatio
n
Hub nodes and edges lesions: most disruptive for network organization & functioning
Network hubs: loci of high variability & plasticity (+maintaining the cortical synchroniz
ation, modularity structure, functional dynamics)