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extraction ratio
Extravasation
first-order process
fraction excreted unchanged
fraction in plasma unbound
fractional rate of elimination
glomerular filtration rate
half-life
hepatic clearance
Log-linear decline
Legend:
Drugs A (black line) and B (colored line) show the same initial (peak) exposure but have different half-lives and total exposuretime profiles
(AUC).A. Regular (Cartesian) plot. B. Semilogarithmic plot. Doses of both drugs are the same.
Legend:
Drugs C (black line) and D (colored line) have the same half-life but have different initial concentrations and total exposuretime profiles.A.
Regular (Cartesian) plot. B. Semilogarithmic plot. Doses of both drugs are the same.
Legend:
Schematic diagram of a perfused organ system.Drug is placed into a well-stirred reservoir, volume V, from which fluid perfuses an extractor at
flow rate Q. The rate of extraction can be expressed as a fraction E of the rate of presentation, Q C. The rate that escaping drug returns to the
reservoir is Q Cout. For modeling purposes, the amount of drug in the extractor is negligible compared to the amount of drug contained in the
reservoir.
Date of download: 9/9/2016
VolumeofDistribution(predicts the
concentration for a given amount in the
body)
Clearance(provides an estimate of the
rate of elimination at any concentration)
First-Order Elimination
fractional rate of elimination, k (elimination rate
constant)