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http://en.wikipedia.org/wiki/Haematopoiesis
http://en.wikipedia.org/wiki/Haematopoiesis
http://en.wikipedia.org/wiki/Haematopoiesis
Cell Morphology
http://www.anatomyatlases.org/MicroscopicAnatomy/Section04/Plat
e0458.shtml
Exercise
http://www.dartmouth.edu/~anatomy/Histo/lab_4/bonemarrow/DMS104/popup.html
Erythropoiesis
Granulopoiesis
Cell Differentiation
Thedeterminismtheory of haematopoiesis,
saying that colony stimulating factors and other
factors of the haematopoietic microenvironment
determine the cells to follow a certain path of cell
differentiation.
This is the classical way of describing
haematopoiesis.
The ability of the bone marrow to regulate the
quantity of different cell types to be produced is
more accurately explained by astochastictheory.
Undifferentiated blood cells are determined to
specific cell types by randomness.
The haematopoietic microenvironment prevails
upon some of the cells to survive and some, on
the other hand, to performapoptosisand die.
http://en.wikipedia.org/wiki/Haematopoiesis
Transcription factors
Growth factors initiatesignal transductionpathways,
alteringtranscription factors, that, in turn activate
genes that determine the differentiation of blood
cells.
The early committed progenitors express low levels
of transcription factors that may commit them to
discrete cell lineages.
Which cell lineage is selected for differentiation may
depend both on chance and on the external signals
received by progenitor cells.
Several transcription factors have been isolated that
regulate differentiation along the major cell lineages.
PU.1 commits cells to the myeloid lineage
GATA-1has an essential role in erythropoietic and
megakaryocytic differentiation.
The Ikaros, Aiolos and Helios transcription factors
play a major role in lymphoid development.[5]
http://en.wikipedia.org/wiki/Haematopoiesis
http://cytometry.nencki.gov.pl/?a=S2vlp8PU
http://commons.wikimedia.org/wiki/File:Fluorescence_Assisted_
Cell_Sorting_%28FACS%29_A.jpg