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Glomerulonephriti
s
GROUP 3
Synopsis
Epidemiology
male
Etiology
General Symptoms
Fever
Headache
Malaise
Anorexia
Nausea and vomiting
High blood pressure
Pallor due to edema and/ anemia
Confusion
Lethargy
Loss of muscle tissue
Edema: starts in the eye lids and face then the lower and
upper limbs then becomes generalized; may be migratory
Clinical syndromes
mixed.
CLINICAL FEATURES
Abrupt
onset of:
hypertension.
DIAGNOSIS
Base line measurements:
- Urea
- Creatinine
- Urinalysis (MSU):
a) Urine microscopy (red cell cast)
b) proteinuria
OTHER :
Electrolyte
Urine culture
Lupus serologies
Anti-DNAase B
(P-ANCA) measurement
(C-ANCA) assessment
Differential
Diagnosis of
AGN
I.
LUPUS NEPHRITIS
II.
IGA NEPHROPATHY
III.
MEMBRANOPROLIFERATIVE GN (MPGN)
IV.
GN OF CHRONIC INFECTION
Lupus Nephritis
Other symptoms can vary from person to person and from day to
day. They may include:
Weightgain
Dark urine
Lupus Nephritis
Physical Examination
IgA Nephropathy
IgA Nephropathy
Membranoproliferative GN (MPGN)
Membranoproliferative GN (MPGN)
cloudy urine
dark urine
GN of chronic infection
The history should begin by focusing on causespecific symptoms to determine the source of the
chronic kidney disease (CKD) if this is unknown.
Recognition of such symptoms facilitates the
planning of further workup and management of
the disease (if systemic).
GN of chronic infection
pruritus
peripheral neuropathy
seizures
tremors
GN of chronic infection
Physical
examination
Hypertension
Pulmonary rales
TREATMENT:
Mainly supportive
Bed rest
PHARMACOLOGIC TREATMENT:
Penicillin
Loop diuretics
Thank
You!