Académique Documents
Professionnel Documents
Culture Documents
HOSPITALIZED
Dr. WIDYATI, MClinPharm, Apt
Farmasis Klinik RSAL Dr. Ramelan
Magister Farmasi Klinik Ubaya
Background Setting
DM in
hospitalize
d
Main
Diseases
Uncontrolle
d DM
Complicatio
ns
Underlying
Diseases
Acute
diseases
Chronic
diseases
2
Uncontrolled DM
Non-adherence
Inadequate OAD
Inadequate insulin
Inappropriate OAD
Inappropriate insulin
Insulin resistence
Insulin tolerance
Infection
Kegagalan OAD
Hiperglikemia
Hipoglikemia
HYPERGLYCEMIA
HYPOGLYCEMIA
Hypoglycemia
Clinical Considerations:
Irregular eating patterns
Physical exercise
Gastroparesis (delayed gastric emptying)
Excessive dose of sulfonylurea
Alcohol ingestion
Drugs Treatment : Ingest 1020 g
rapidly absorbed carbohydrate. Repeat
in 1520 min if glucose remains <60
mg/dL or if patient is symptomatic.
If patient is unconscious : Glucagon 1 mg
SC, IM, or IV (response time, 6.5
Non-Adherence
Acute
Metabolic
complicatio
ns
Hyperosmolar
Hyperglycemia
State (HHS)
Ketoacidosis
Chronic
Complicatio
ns
Makrovaskuler:
cardiovascular
disorders,
Peripheral
Vascular Disease
Mikrovaskuler:
Retinopati,
Nefropati,
Neuropati
8
HYPERGLYCEMIC CRISES
Hyperosmol
ar
Hyperglyce
mia:
Diabetic
ketoacidosis
:
Common acute
complication of DM Type1
Criteria: FPG>250 mg/dl,
pH < 7 (severe)-7,3; Keton
(+) dlm urin/serum,
osmolalitas variable; alert9
coma
Requires correction of :
dehydration,
hyperglycemia,
electrolyte imbalances;
identification of comorbid
precipitating events
Insulin Therapy
Chronic
Complications
1. CARDIOVASCULAR
DISEASE
BLOOD PRESSURE
CONTROL
MANAJEMEN
DISLIPIDEMIA
15
MANAJEMEN
DISLIPIDEMIA
Lipid Profile
Monoterapi
Terapi
Kombinasi
Resin+Niacin/St
atin or Statin +
Niacin
LDL , TG
TG
Statin
Niacin
Fibrate
Statin+Niacin
Niacin + Fibrate
LDL , HDL
Niacin
Statin
Statin+ Niacin
16
Terapi Anti-Platelet
2. NEPHROPATHY
3. RETINOPATHY
4. NEUROPATHY
Intercurr
ent
illness:
Trauma,
surgery
Acute
events:
Stroke,
ACS,
Sepsis
Acute
Disease
s+
DM
Comorbid
:
dislipide
mia, HT
21
INTERCURRENT
ILLNESS
9-8-15
22
Comorbid Conditions
Atherosclerosis
Dyslipidemia
Hypertension
Associated with
cholesterol (esp. LDL)
Occur primarily in large
& medium arteries
Aggressive treatment
include plaque
stabilization with aspirin
or ACE
Intensive treatment is
important for protection
from macrovascular
complications
Treatment:Statins,
Fibrates, Bile acid
sequestrant, Nicotinic
acid,Ezetimib
UKPDS: Intensive
control of BP reduces
Diabetic complications
by 24%
Diabetes related deaths
by 32%
Strokes by 44%
Heart Failure by 56%
Microvascular
Complication by 37%
Treatment: ACE or blocker
23
DM in Acute Events
Seps
is
Stro
ke
ACS
24
25
DM in Chronic Diseases
26
BLOOD GLUCOSE
TARGET
TREATMENT OPTIONS
OAD:
Sulfonilurea dan meglitinide tidak
direkomendasikan karena risiko hipoglikemia
pada pasien yang tidak mengkonsumsi diet
normal, sulitnya penyesuaian dosis
Metformin memberikan risiko lactic acidosis
khususnya pada COPD, renal insuff,hipoperfusi,
CHF, manula.
Thiazolidinedion: delayed onset, mevolume
intravaskuler
Insulin
Dosis Insulin
TDD Estimation
Patient Characteristics
Underweight
Older age
Hemodialysis
Normal weight
Overweight
Obese
Insulin resistant
Glucocorticoids
Current
Recommendation
Why?
Current
Recommendation (cont.)
DRUG INDUCED
HYPERGLYCEMI
A
Glucocorticoids
Corticosteroids
Diuretics
Diazoxide
Pentamidine
Protease inhibitors
Cyclosporine
39
Disopyramide
Ethanol
Pentamidine:occurs days to 2 weeks
after initiation of therapy
SU, Insulin
40
Case 1
41
Case 2
Tn H, 59 th, 50 kg TB 163 cm
MRS dengan DM Hiperglikemi, luka di kaki
yang kotor. Obat DM yang terakhir diminum
adalah Glucodex 1-1-0, metformin 3x850mg
disertai riwayat hipertensi yang terkontrol dg
Diltiazem 3 x 30 mg; Captoril 3x25mg,
Aspirin1x100mg
BP: 170/110 mmHg, GDA 529 mg/dl
Apa rencana farmasis?
42
Online Resources
Texas Diabetes
Council:www.tdctoolkit.org/algorith
ms-guidelines/
ADA
NDEP
Summary