Acantholytic acanthoma

(Epidermolytic acanthoma)

Deba P Sarma, MD
Omaha
 M 65, neck

Compact hyperkeratosis, acanthosis, papillomatosis

Acantholysis with periperinuclear vacuolization
involving all layers of the epidermis except the basal
layer
Hypergranulosis with large basophilic keratohyanine
granules and intracytoplasmic amorphous
eosinophilic bodies
 Acantholytic acanthoma
(Epidermolytic acanthoma)

Single asymptomatic papule or nodule in trunk, arms,

neck; genital lesions may be multiple.
Age: Elderly (median age 60), M>F

 Benign epidermal tumor with a characteristic histologic

picture of acantholytic hyperkeratosis.

 Compact hyperkeratosis, acanthosis, papillomatosis.

 Acantholysis with periperinuclear vacuolization involving

all layers of the epidermis except the basal layer.

 Hypergranulosis with large basophilic keratohyanine

granules and intracytoplasmic amorphous eosinophilic
bodies.