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2Carbohydrate
and Fat Metabolism
Contd
Main storage sites in the body:
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Insulin also starts buildingglycogen from
glucose;fats (triglycerides) from glycerol
and fatty acids; andproteins from amino
acids (stimulates anabolic reactions)
The activity of lipoprotein lipases
depends upon the levels of insulin in the
body. If insulin is high, then the lipases
are highly active; if insulin is low, the
lipases are inactive.
.
Contd
The fatty acids are then absorbed
from the blood into fat cells, muscle
cells and liver cells.
In these cells, under stimulation by
insulin, fatty acids are made into fat
molecules and stored as fat droplets
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Glucagon is released from the pancreas
in response to low blood glucose.
epinephrine is released in response to a
threat or stress.
Both hormones act upon enzymes to
stimulate glycogen phosphorylase to
begin glycogenolysis and inhibit glycogen
synthetase (to stop glycogenesis).
Contd
Glycogen is a highly branched polymeric
structure containing glucose as the basic
monomer.
First individual glucose molecules are
hydrolyzed from the chain, followed by
the addition of a phosphate group at C-1.
In the next step the phosphate is moved
to the C-6 position to give glucose 6phosphate, a cross road compound.
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Glucose-6-phosphate is the first step
of the glycolysis pathway if glycogen
is the carbohydrate source and
further energy is needed.
If energy is not immediately needed,
the glucose-6-phosphate is converted
to glucose for distribution in the
blood to various cells such as brain
cells.
Outline lipolysis
When glycogen stores are not available in the
cells, fat (triacylglycerol) is cleaved to provide 3
fatty acid chains and 1 glycerol molecule in a
process known as lipolysis.
Lipolysis creates acetyl CoA molecules which
can then enter the Krebs Cycle.
During fasting:
Levels of glucagon and adrenaline
(epinephrine) both increase
Glugacon causes release of glucose from
glycogen stores in the liver and skeletal
muscle
(NOTE: skeletal muscle stores are only
useful to the muscles they are stored in.
Once suppllies are depleted in your
biceps, reserves from the triceps can not
be funneled to other muscles)
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Additionally, both of these hormones
are lipolysis inducers mobilizing fat
stores from the bodys adipose
tissues for breakdown into useful
energy
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Increased muscle contraction leads
to increased muscular perfusion
perfusion is the process of delivering
blood to a capillary bed in the
biological tissue.
More blood delivered to a capillary
bed during exercise = more content
of that blood (glucose, O2etc)
delivered to the cells that need it
most