White blood cell

(neutrophil)
 The white blood cells
The white blood cells are consist of 3 major
types containing:

Granulocytes, Monocytes and

Lymphocytes.

e
Not
There are also more subtype of white blood cell which
s:each work on different functions, but the type that we
are focusing on is Neutrophil which is the sub-type of
Granulocytes.
 The
More
The white blood cells: Types Know! You

Granulocytes: 3 Monocytes: Develop into 2

forms types of cell

- Neutrophil - Dendritic

- Eosinophil - Macrophages

- Basophil
Lymphocytes: 2 main types

- B Lymphocytes
According to this websites:
- T Lymphocytes http://www.diabetes.co.uk/body/wh
ite-blood-cells.html
Neutroph
il
Neutrophil is the part of our immune system which made up of 60% in
immune cells in the blood.

That means, Neutrophil has a very important job of keeping away

those invaders that came inside the body.

Polic V Bad
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Possible Location of Neutrophil
- Located in the membrane bound in blood vessel throughout our body

- Because its job which is traveling throughout the body to eliminate

bacteria, virus and other intruders that leaked inside the blood system.
Shape of
Neutrophil
This type of white blood cell has the size ranging between 9 to 12
micrometer. Neutrophil also has a complex and Lobulated shape.
List of organelles in neutrophil vs general
animal cell
Neutroph General
il Animal Cell
Nucleus lobes
Nucleus
Golgi body
Golgi Body
Ribosome
Ribosome
Mitochondria
Mitochondria
Cytoplasm
Cytoplasm
Phagosome

Granuel Vacuole

Glycogen Lysosome
Specialized organelles and features in
Neutrophil
Nucleus lobes

Granule (Primary,
Secondary)

Glycogen
These organelles are called
Phagosome
differently from the original
ones
Nucleus lobes = Nucleus

Granule = Lysosome

Glycogen =
Polysaccharides
Neutrophil shape and its function
The lobulated shape of Neutrophil increase the flexibility of the
cell so that it can do phagocytosis process (A process of
engulfing intruders).
This helps in the immune system
for getting rid of the invaders such
as virus bacteria and prevents the
body from getting disease.

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In the time
Know
of its living, it can
destroy up to 250 of invaders.
Explanation of the Phagocytosis
Phagocytosis is a process which neutrophils binds bacteria into the cell.
This process will occur when neutrophils want to destroy the bacteria.
u
How phagocytosis happen? M o re Yo
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now
KNeutrophils
1.Neutrophil makes a contact with the invader. phagocytosis
contains the basic
2.Neutrophil binds the invader inside it. process of white
blood cells.
3.Neutrophil takes it to the Phagosome that locates inside Neutrophil.

4.Granule (Lysosome) merge into the Phagosome to digest the

invaders. This organelle becomes Phagolysosome.

5.Phagolysosome releases the waste from digesting out into the

https://www.youtube.com/watch?v=Z_mXDvZQ6dU for some idea what is happening
Neutrophil.
Brief Life cycle of the Neutrophil
- Firstly, Neutrophils are, like other white blood cells, produced in
Bone Marrow and are related to Bone Marrow in the first place.

- They are able to flow in the blood for around 8 - 10 hours long.

- After produced from the Bone Marrow, they will be transported into
the tissue space (the space between cell).

- After transported, Neutrophil cant go back into the Bone Marrow

again.

- Its life will end within 1 - 4 days.

- After Neutrophil ate something, it will die.

Neutrophil Related Disease
- Neutropenia is a Neutrophil related disease. It makes the affected
person has less Neutrophil, which would lower the efficiency of
immune system

- Examples of the Neutropenia related disease

- Cyclical Neutropenia

- Antibody Mediated Neutropenias

- Severe Congenital Neutropenia (SCN)

- Antibody Mediated Neutropenias

Causes & Symptoms
- There are many causes that can cause you Neutropenia such as
Chemotherapy, Leukemia, Radiation therapy etc. (people who are
over 70 years old also have a chance to have Neutropenia)

- The symptoms / noticeable sign of affection of Neutropenia can be

such symptoms as low fever, rashes etc.
Cure & Treatment
- There are many ways that we can cure Neutropenia. In the case
that its not a serious case it may not need to have a treatment.

- Granulocyte colony stimulating factor or what we call GCS-F is a

treatment which will produce more neutrophil from bone marrow by
stimulates.

- Stem cell transplant are also used to treat Neutropenia.

Our Models description

Please handle with Just in case

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 Referenc
es:
The Editors of Encyclopdia Britannica (2016, October 17). Neutrophil. In Encyclopdia Britannica. Retrieved January 25,

2017, from https://global.britannica.com/science/neutrophil

White Blood Cells. (n.d.). Retrieved January 25, 2017, from http://www.diabetes.co.uk/body/white-blood-cells.html

Organelles. (n.d.). Retrieved January 25, 2017, from http://biology.tutorvista.com/animal-and-plant-cells/organelles.html

Metzler, K. (2003). Neutrophils: Definition & Function. Retrieved January 24, 2017, from

http://study.com/academy/lesson/neutrophils-definition-function-quiz.html
 Referenc
es:
Higuera, V. (2016, April 20). WBC (White Blood Cell) Count. Retrieved January 25, 2017, from

http://www.healthline.com/health/wbc-count#Overview1

Chromatography YouTube Channel (Producer). (2012, January 23). How White Blood Cells Work [Video file]. Retrieved

January 25, 2017, from https://www.youtube.com/watch?v=0TvTyj5FAaQ

Neutrophil Disorders. (n.d.). Retrieved February 5, 2017, from

http://www.mottchildren.org/conditions-treatments/peds-neutrophil-disorders

Neutropenia: Causes, Symptoms, and Treatment. (n.d.). Retrieved February 01, 2017, from

http://www.webmd.com/a-to-z-guides/neutropenia-causes-symptoms-treatment#1
 Referenc
es:
Neutrophil. (2014, June 14). Retrieved February 4, 2017, from http://www.wellness.com/reference/allergies/neutrophil

Neutrophil kinetics in health and disease. (n.d.). Retrieved February 4, 2017, from

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930213/

Neutrophil disorders and their management. (n.d.). Retrieved February 01, 2017, from http://jcp.bmj.com/content/54/1/7.full

Phagocytosis. (n.d.). Retrieved February 5, 2017, from

https://www.khanacademy.org/test-prep/mcat/cells/transport-across-a-cell-membrane/a/phagocytosis
 Referenc
es:
http://emedicine.medscape.com/article/204821-overview?pa=GHtT6eKV65lAE1J0Ksl9B2X6RkEkkXwRGWxYsFeCmdd
D4mzwWnGZCdino8TGzmj5HVFU4eaxtVTdJHnpTx2prCwhCTQq25Ki1mL6i64Z7Vg%3D

Neuman29. (n.d.). Neutrophil Life Cycle. Retrieved February 5, 2017, from

https://quizlet.com/27240832/neutrophil-life-cycle-flash-cards/
Thank You Everyone!
By: Prop Min Time PK Pat