Académique Documents
Professionnel Documents
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Penyaji
Suluh Bayu Waskito, S.Ked
Background and Purpose
?
Background and Purpose
Menguji hipotesis
bahwa konsumsi
alkohol dapat
menjadi resiko
stroke iskemik
case- crossover
approach
Variasi resiko
lamanya waktu dari berbagai
Munculnya
antara intake macam jenis
gejala
alkohol minuman
alkohol
Methods
January 2001
- November
2006
Results
Reported
390 patients
248
(64%) 14
104
reported within 1 hour
alcohol within 24
of stroke
consumption hours
onset
in the prior
year
Conclusions
Resiko
munculnya
onset stroke
sementara
terlihat
meningkat pada
jam setelah
konsumsi
alkohol
1st
hypothe
sis
Documented :
have acute
potentially
deleterious
physiological
effects within
hours after
consumption
2nd Aktivit
hypothe as
sis Fibrin
sensiti olitik
vitas
insulin
dan Konsum Profil
adipo si lipid
kinesi alkohol
s dalam
jumlah
sedang
Solubl
e
efek Inflam
vascul
protekti mator
ar
f y
adhesi
marke
on
Flow- rs
molec
ules media
ted
vasodi Hours,
latatio weeks,
n or years
METHODS
Study
Populatio
n
January
2001
-Novem
ber
2006
Study
Populatio
n
0 - 14 days after
acute ischemic
stroke
(@35 45
minutes)
209 men
390 patients
interviewed
181 women
Include
Charateri
stic
Had poor
memory around
the time of the
stroke
Exclude
Experienced
aphasia
Unable to
complete the
structured Too ill to
interview complete the
structured
interview
43%
Patients with confirmed ischemic
stroke met all inclusion criteria
12,5%
discharged
from the
hospital
5.5%
83% agreed before the
refused
interviewers
were able to
approach
them
?
Interview
Structured
questionnaire
Date and time
of first
symptoms
?
Asked patient
Consumed any
alcoholic
beverage in the
year before
their stroke
last time
Ask consum
them ed an
alcoholic
? beverag
e
Patients Usual
Types of reported frequency
alcohol of
consume any alcohol
d (beer, alcohol consumpt
wine, or ion over
liquor) consump the prior
tion year
A serving size
Usual
of alcohol : number
12 ounces of of
servings
beer consume
4 ounces of wine d each
1,5 ounces of time
liquor straight or
in a mixed drink
Also
ask this
?
Caffein
e
Sympto
ms on Cigaret
the day te
of the smokin
Last g,
stroke exposure
to other
potential marijua
triggers na
and usual
frequenc
y of
these
factors
Medica over the
tion prior
use Cocaine
year
Stress,
anger,
and
physica
l
activity
RESULTS
PRIOR YEARS
PRIOR
YEARS
Median Amounts =
Median
1 drink
Frequency =
(only 13 drinking > 2
2 times per week
servings)
Founded
169 subjects
reported exposure
week before stroke
104 subjects
drank alcohol within Founded:
24
hours of stroke 1 hour after
onset alcohol
consumption,
the risk of
stroke onset
14 subjects
2.3 x higher :
drank within 1 hour of non use
stroke
onset
Alcohol
Type
Exposure
other
potensial
triggers
14 people exposed
248 participants
lo
exposed to alcohol
alcohol in the hour
in the prior
before stroke
year
onset
4
were also
63 participants
exposed
exposed to other
to vigorous
potential triggers
physical activity
in the hour before
stroke onset
1
drank a
caffeinated
beverage
DISCUSSION
In This
study
found that moderate( 151
Hiilbo
to 300 g) and heavy
(>300 g) consumption of
alcohol within the week
Goreli
coexposures
including smoking, there
was no statistically
ck significant
increase in risk of
ischemic stroke in the 24
hours after
alcohol consumption
Previous Impaire
Study d
fibrinol
ysis
Modera
te and
Heart high Platelet
rate intakes activati
of on
alcohol
Blood
pressur
e
Increasing
Heavy the
consumptio Dehydration transient
n risk of
stroke
Solubl
e
protecti Inflam
vascul
ve mator
ar
effects y
adhesi
marke
on
Flow- rs
molec
ules media
ted
vasodi Hours,
latatio weeks,
n or years
Other Studies
Not
associated Protective
with stroke Increased
risk risk of
isehcmie
stroke
SUMMARY
Summa
ry