Pathology

Male Genital System

Male Genital System
Gross
Pictures taken from Lab Validation
Seminoma
- Produce bulky masses,
sometimes ten times the size of
the normal testis
- Homogenous, gray-white
lobulated cut surface, usually
devoid of hemorrhage or necrosis
- Generally, tunica albuginea is not
penetrated, but occasionally
extension to the epididymis,
spermatic cord, or scrotal sac
occurs
- Most common type of germ cell
tumor
- Dysgerminoma in ovaries
Nodular
Hyperplasia
(BPH), prostate
- Originates almost exclusively in
the inner aspect of the prostate
gland (transition zone)
- Early nodules are composed
almost entirely of stromal cells,
and later epithelial cells arise
- Nodular enlargements may
encroach on the lateral wall of
the urethra to compress it to a
slitlike orifice
Adenocarcinoma,
prostate

- In 70% of the cases, arises in the

peripheral zone of the gland,
classically in a posterior location,
where it may be palpable
- On cross section, neoplastic
tissue is gritty and firm, but when
embedded within the prostatic
substance it may be extremely
difficult to visualize and be more
readily apparent on palpation
Condyloma
acuminatum

- At gross inspection, condylomata

often appear friable, papillary,
and vegetative in nature, and
they can be multifocal and
multicentric, varying in both
number and size. The lesions can
be so extensive that they disrupt
the normal appearance and
anatomy of the external genitalia
(Medscape)
Squamous cell
carcinoma, penis

- Predominant growth patterns are

vertical and superficial spreading
- Gross aspect is non-distinctive
and variable
- Mean tumor size varies from 2
cm in low incidence areas to 4-5
cm in high incidence areas
- Cut surface shows tan-white solid
irregular tumor with superficial or
deep penetration
Immature
teratoma
- Usuallr large, ranging from 5 to
10 cm in diameter
- Composed of various tissues;
gross appearance is
heterogenous with solid,
sometimes cartilaginous and
cystic areas
- Helter-skelter collection of
differentiated cells or organoid
structures
- In the postpubertal male, all
teratomas are regarded as
malignant
Male Genital System
Histology
Seminoma
- Sheets of uniform cells divided
into poorly demarcated lobules
by delicate fibrous septa
containing a lymphocytic
infiltrate
- Large and round to polyhedral
and has a distinct cell membrane;
clear or watery-appearing
cytoplasm; and a large, central
nucleus with one or two
prominent nucleoli
- Cytoplasm contains varying
amounts of glycogen
- Slides taken from lab validation
Nodular
Hyperplasia
(BPH), prostate

- dilatation, proliferation and

hyperplasia or acini
- Glandular hyperplasia, absence
of nucleoli
- Glands separated by thin fibrous
tissue
- Dual cell population (HPO): the
inner columnar and outer
flattened basal cell (less likely to
be seen in our slide)
Adenocarcinoma,
prostate
- Glands are smaller than benign
glands, and lined by cuboidal or
low columnar cells
- Prostate cancer glands are more
crowded, and characteristically
lack branching and papillary
infolding
- Fused glands
- Most reliable feature is nucleoli
which indicates malignancy
- Cytoplasm of the tumor cells
ranges from pale-clear to a
distinctive amphophilic
appearance
- General pleomorphism is not
marked; mitotic figures are
uncommon