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Oleh
Tommy arean
Latar belakang
PDA (Patent ductus Arteriosus)
Komplikasi RDS pada bayi prematur
60 - 70% obat atau pembedahan
RDS + PDA gagal napas, PIV,BPD,
NET
NSAID dan Ligasi
NSAID
Standarnya : indometasin dan ibuprofen
Keberhasilan 70-80%
Efek samping
Ggn sal. Cerna (perforasi)
Gagal ginjal akut
Hiperbilirubinemia (ibuprofen)
Keamanan
Perdarahan GIT dan hiperbilirubinemia
5 NICU di italia
Kriteria inklusi
Usia kehamilan 25 +0 hingga 31 +6 mgg dan
Fetal hydrops.
sample at birth.
pressure.
Serum creatinine concentration >1.5 mg/dl (132 mol/l).
and AST/GOT) >2 times the upper boundary of the normal range.
Secondary endpoint
Closure rate of PDA after the first and second day of the first treatment course
Closure rate of PDA after the second course of treatment with ibuprofen
and isolated perforation) within 30 days. For study purposes, the renal failure is
defined as a serum creatinine concentration >1.5 mg/dl (132 mol/l) and urine
output <1 ml/kg/h during a 24-h collection period. Liver failure is defined as
elevated liver enzymes more than two times the upper boundary of the normal
range (normal ranges: ALT/GPT = 650 U/L and AST/GOT = 35140 U/L) [34].
PATIENT TIMELINE
Uji statistik
Karakterisitik klinis :
Rerata, median, range, frekuensi dan
persentase
Analisis univariat
T test (parametrik)
Early vs late
Rejimen dosis analgesik yang biasa diberikan di NICU
dan toleransinya baik
Paracetamol dapat menjadi pilihan terapi HsPDA, terutama
karena rendahnya efek samping.