SpineRepair RTD

2013

SPINEREPAIR
Hybrid CMOS-polymer neural interfaces
for restoration of sensorimotor functions
after spinal cord injury
Co-PIs:
EPFL S.P. Lacour, G. Courtine, S. Micera
ETHZ J. Vrs, A. Hierlemann
CSEM A-S Porret
Spinal Cord Injury

MUSCLES
 Spinal Cord Injury

COMPLETE AND PERMANENT PARALYSIS

X
SpineRepair Restoring leg motor functions

OBJECTIVES: A SPINAL NEUROPROSTHETIC SYSTEM

Define the mechanistic framework of

hindlimb motoneurons

Design and manufacture long-term

spatially selective spinal implants

Customized electronic hardware

Spatio-temporal software development

Chronic evaluation in animal models

 Scientific & Technical Outcomes
MECHANISTIC H A R D WA R E D E S I G N CUSTOMIZED
FRAMEWORK ELECTRONICS
e-dura
spinal implant
20m

2.76mm
drug delivery

elastic
interconnect

3 mm electrode

S O F T WA RE Custom CMOS stim. chip

D E V E LO P M E N T

Spatio-temporal development

Telemetry & power mgt

J. Neuroscience | 2013 | 33(49):19326 IEEE Transactions on Circuits and

Neuron | 2016 | 89 (4), 814-828 Validation in rodents Systems II | 2015 | 62(6), 527-532
Science | 2015 | 347(6218) 159 Science Trans. Med. | 2014 |
Nature Medicine | 2016 | 22, 138-145 (255):255ra133
 Space and time control
of spinal neuromodulation

Nature Medicine | 2016 | 22, 138-145

 Translation to Non Human Primates

Collaboration with new partners

E. Bzard

E. Rouiller J. Bloch
 Translation to Non Human Primates
Wireless
Neurostim.
0110001010
0101011101
01010101

T. Denison

Spinal Implant Brain

motor
cortex
recording
D. Borton
 Brain-Spinal Interface
Lateral Hemisection 6
D AY S ON
BRAIN
CONTROL

HUMAN READY
TECHNOLOGY

Nature | 2016 | 539(7628):284-288

 Additional Scientific Outcomes
High performance stretchable conductors

Ag NW

Lithography patterning Filtration patterning Wireless bladder volume

monitoring

ACS Appl. Mater. Interfaces | 2015 | 7, Small |2016 | 12, 180184

1346713475 (2015). Adv. Mater. | 2016 | 28(33):7200.
Sci. Rep. | 2016 | 6, 25641 2 patent applications

Biphasic (liquid-solid) stretchable conductors

Bright stretchable displays
a b

solid AuGa2 -
liquid Ga One patent application
500 substrate 5 mm Adv. Mater. | 2016 | 28(22):4506.
nm
c
d AuGa2 (111)
a.u.)

(220)
Dynamic and truly interdisciplinary consortium!
 Dissemination

5 PhD students (NextStep Entrepreneurial program)

15+ Journal publications

> 25 international conference contributions

Materials Research Society
IEEE conferences
Society of Neuroscience

4 patent applications (pending)

Outreach activities
EPFL open doors
Media: RTS, France 2, Le Temps, scientific magazines