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DRUGS
Physical Chemical
Melting Point pH
Functional Group
QUESTIONS
1. What are the requirements for a drug to exert
its biological effect?
Ionic
Bonds bond formed by the attraction between
atoms of opposite charge
RECEPTO DRUG-RECEPTOR
DRUG R COMPLEX
PHARMACOLOGICA
L EFFECT
BIOTRANSFORMATION REACTIONS
Phase 1 Functionalization Phase 2 Conjugation
Reactions Reactions
Glucuronic Acid
Conjugation
Oxidative Reactions Sulfate Conjugation
Methylation
QUESTIONS
1. What is Biotransformation?
Age Differences
Species and Strain Differences
Hereditary or Genetic Factors
Sex Differences
Enzyme Induction and Inhibition
Miscellaneous Factors
QUESTIONS
Me Salicylate
Aspirin
ANSWERS TO QUESTIONS
2. What are the pharmaceutical and medicinal uses
of salicylic acid?
Salicylates = NSAID
METABOLISM OF SA
SA glucosyltransferaseconverts SA to
Its metabolite SA glucoside.
SYNTHESIS OF ACETYLSALICYLIC
ACID
3 g of Salicylic acid + 6 mL acetic anhydride
+ 85% phosphoric acid
Heat 10 mins in beaker
Distilled water
+ 20 mL water then COOL
= _____?
PERCENT YIELD
=
= ___?
PHYSICAL PROPERTIES
Color = white
Odor = odorless
Appearance = crystal figures
Corticosteroids
Ibuprofen
ANSWERS TO QUESTIONS
6. What is the storage requirement for salicylic
acid?
Store at room temperatue.
Away from moisture and light
Do not use if ASA has vinegar smell.
METABOLISM OF
ACETYLSALICYLIC ACID
Glucuronidation
Active metabolite : Salicylate
SYNTHESIS OF METHYL
SALICYLATE
60 mL methanol + 27.6 Salicylic acid
H2SO4, swirl
reflux 2 hrs
cool in iced bath
= _____?
PERCENT YIELD
=
= ___?
PHYSICAL PROPERTIES
Color = white
Odor = odorless
Appearance = crystalline powder