HIV -

1
Cabrera Hernndez Jos Luis
Mino Mendoza Luz Elena
Morn Erchuk Mara
Fernanda
Human immunodeficiency virus
Genus:
Lentivirus
Out layer

Phospholipid
membrane

gp41 gp120
(transmembra (surfac
ne) e)
Internal capside

1.viral ARN
2.Nucleoprotei
n p7
3.enzymes
VIRION PROTEINS

MA: matrix protein

CA: capside protein

NC: nucleocapsid protein

VIRAL ENZYMES

PR (protease) = divides the polyprotein

Gag-Pol

TR (inverse transcriptase) y RNAsa=

polymerase of DNA dependent of RNA---
that sintetize DNA of RNA

IN (integrasa)= catalyze the insertion of

the DNA
VIRULENCE
FACTORS
INFECTION CELL
TO CELL
Spiny cells:

1.LT CD4 & CD8

2.monocytes
3.macrophages
4.microglia
5.Langerhans cells
STAGES OF THE
INFECTION

ACUT CHRON AIDS

E IC
 INFECTION

Early Phase ---------- integration of DNA with the cell gens Late Phase ---------- transcription
TRANSMISSION
Phatogenesis

Mediated
CCR5 by gp41
CXCR4
 HIV-1

Global
pande
mic

RNAs
s

Nucleus gp120 & Inverse

proteins gp41 Transcriptase
 A B C
Asymptomatic Bacillary AIDS
angiomatosis
Lymphadenopathy Oral candidiasis

STAGES
 AIDS
Common General Infectious
manifestations manifestations manifestations
Infections Chronic diarrhea Otitis
Fever Chronic TB
lymphadenopathy
Weight loss Hepatomegaly Pneumonia
Hyporexia Splenomegaly Measles
Malnutrition Parotitis toxoplasma
 PNS CNS Cardiologic
manifestations manifestations manifestations
Peripheral neuritis Generalized Left Ventricular
encephalopathy Hypertrofy
Radiculopathies Psychomotor Heart failure
regression

Weakness

Ataxia

Convulsions
DIAGNOSIS

Medical
history

ELISA (EIA)

Western Blot
Treatment
Reverse Non-nucleoside Fusion inhibitor Integrase inhibitor Nucleoside
transcriptase analogues reductase inhibitor
inhibitor

Zidovudina Nevirapina Enfuvirtida Raltegravir Hidroxiurea

BIBLIOGRAPHY
1.- Instituto Nacional de Seguridad e Higiene en
el trabajo. Virus de Inmunodeficiencia humana.
Septiembre 2014.

2.- Trujillo J Roberto, Boursiquot R, Ramrez

Rodrguez Claudia, Ancer Rodrguez Jess, Essex
Max, Major E O. La biologa molecular del
neurotropismo del VIH-1. IMBIOMED [en linea]
2016. [fecha de acceso 11 abril de 2017].
Disponible en:
http://www.imbiomed.com.mx/1/1/articulos.php
?method=showDetail&id_articulo=21283&id_secc

3.- P. R. MURRAY. Microbiologa Mdica. 2006. Mosby.
Espaa: Elsevier Science; 2009
4.- Romero C. Raul. Microbiologia y parasitologia
humana. 3 ed. Madrid: Panamericana; 2007.
5.- CENSIDA. NORMA Oficial Mexicana NOM-010-
SSA2-2010, Para la prevencin y el control de la
infeccin por Virus de la
Inmunodeficiencia Humana: 2010 [19 abril 2017].
http://www.censida.salud.gob.mx/descargas/drhuma
nos/NOM-010-SSA2-2010.pdf
 6. La biologa molecular del neurotropismo del VIH-1.
[Internet] Imbiomed.com.mx. 2004 [cited 27 April
2017]. Available from:
http://www.imbiomed.com.mx/1/1/articulos.php?
method=showDetail&id_articulo=21283&id_seccion=11
30&id_ejemplar=2190&id_revista=91
7. Biologa molecular del sida [Internet]. Biologia.edu.ar.
2017 [cited 27 April 2017]. Available from:
http://www.biologia.edu.ar/virologia/hiv1biologiamolecul
ar.htm