Académique Documents
Professionnel Documents
Culture Documents
References:
1. Tumor Immunology and Cancer Vaccines
(Samir Khleif, Publisher: Springer; 1st edition 2005)
2. Cancer Immunotherapy-Advances in Immunology, Vol.
90 (James Allison, Glen Dranoff; Publisher: Academic
Press 2006)
Goals of This Course
1. Attendance 60%
1. Tumorigenesis
2. Discovery of the protective immune
response against tumors.
3. T cells recognize specific antigens on
tumors
4. Tumors can escape in many ways
5. Immunotherapy for tumors
How does cancer arise?
Dysregulated cell growth & proliferation
=> Transformation
1. Tumorigenesis
2. Discovery of the protective immune
response against tumors.
3. T cells recognize specific antigens on
tumors
1. Tumorigenesis
2. Discovery of the protective immune response
against tumors.
3. T cells recognize specific antigens on tumors
Treg infiltrating
Tumors w/Fas
Tumor loss of MHC-I as a evasion
mechanism
Immunoediting
of Cancer
1. Tumorigenesis
2. Discovery of the protective immune
response against tumors.
3. T cells recognize specific antigens on
tumors
4. Tumors can escape in many ways