Table 27-6 Various Chemotherapy Regimens for Germ Cell Tumors Regimen 1(PEB) _ <12 Months of Age (Every 3 Weeks) _ =12 Months of Age (Every 3 Weeks) Cisplatin (P) 0.7 mg/ky/lV Days 1, 2, 3,4and5—— 20mg/m*/lVon Days 1, 2,3, 4and 5 Eroposide (E) 3 mg/kg/IV Days 1, 2, 3, 4and 5 400 mgim’/IV over Days 1, 2,3, 4and 5 Bleomycin (B) 0.5 units/kg/IV Day 1 1S unieeym?/IV on Days 1 oR Regimen 2 JEB) Carboplatin {600 mg/m'/lV Day 4 Exoposide 120 mg/m"/lV Days 1, 2 and 3 Bleomycin 15 units/m? Day 3 Disease ic evaluated in weak 12 after our cycles. IF complete remission then discontinue chemotherapy. partial romicsion| then surgery (week 12) followed by two mare cycles of chemotherapy at above (weeks 13 and 16). Table 27-7 Chemotherapy Regimens for Malignant Germ Cell Tumors ‘Sie Histology “Therapy Testicular Stage Radical inguinal orchiectomy only Testicular Stage EB or JES every 3 weeke for Four cycles Testicular Stages Ill and IV. PEB or JEB every 3 weels, for four cycles followed by surgery Ine disease (CR), discontinue therapy, if PR, ewo more cycles and repeat surgery Ovarian Stages land Il PEB or JEB every 3 weeks for four cycles Ovarian Stage: ll and IV PEB every 3 weeks for four cycles followed by surgery IFCR, discontinue therapy; iF PR, 2 more cycles and repeat surgery Malignant Stages I-IV PEB every 3 weeks for 4 cycles followed by surgery aragonadal IFCR, discontinue therapy, IF PR, 2 more cycles and repeat surgery sgermeell Immature Surgery alone “IFAFPis increased, chenotherapy as per Table 27-6. _Albreristins: CR. complete remision: PR. partial remission