Académique Documents
Professionnel Documents
Culture Documents
Permeate
Crossflow Microfiltration
Feed
Retentate
Membrane
Permeate
Membrane Filtration
Mechanical separation processes for
separating gaseous or liquid
streams.
Separation with the help of permeable
membranes
Wide range of separations - of
miscible components.
Operate without heating
Separation based on size and shape.
Membrane Filtration Types
1. Pressure driven types: 2. Concentration gradient
driven:
Microfiltration(MF)
Dialysis
2. Mechanical stability
3. Chemical stability
4. Flux rate
5. Ease of sterilization
6. Cost
Types of Membranes
I. Polymers membranes
cellulose acetate
Polyvinylidene fluoride (PVDF)
Polyethersulfone (PES).
II. Ceramic membranes
Chemical resistance, steam sterilized, longer life time ( 10yrs)
High initial cost
Configuration of UF Unit:
Applications:
1. Concentration:
2. Purification: Solvent & low MW product
separation from high MW components
3. Useful in removing pyrogens, cell debris and
virus from media.
4. processing of antibiotic broths, DNA purification,
monoclonal antibodies purification, whey
fractionation and lysozyme purification
Advantages:
Ultrafiltration can be operated in various mode Energy Efficient, Inexpensive,
including diafiltration, high-performance Nondestructive & easy to operate
tangential flow filtration (HPTFF) and affinity
ultrafiltration
Diafiltration :
impermeable
Reverse osmosis
Pressure (10-100bar) is applied to the solvent molecule against
concentration gradient.
Solvent moves from low to high conc.
P >
(Osmotic pressure) = CRT;
C Conc. of solute, R- Gas constant, T- Temp.
Reverse osmosis
Reverse Osmosis
RO membranes are effectively non-porous and, therefore,
exclude many low molar mass species such as salt
ions, organics, etc
Membrane pore size-0 .0001 - 0.001 m
Operate in pressure range of 10-100 psi
RO membrane allowing passage of solute molecules.
Solute transport Diffusion or Convection
Concentrated solution becomes even more concentrated
Membrane configuration cross flow.
Cross-flow Vs Dead-end
Cross-flow RO
Reverse Osmosis/ Hyperfiltration
Water Flow
Product
Feed
Concentrate
Ions
Membrane
1. Cellulose acetate
2. Polyamide hydrocarbon (PAH)
3. Sulfonated polysulfone (SPS)
Applications:
Potable water from sea or brackish water.
RO for selective wine filtration was patented in 1992 for volatile acidity (VA) and alcohol
removal in wine1.
RO is a cross-flow process where only very small molecules pass through the membrane,
leaving flavor and aroma constituents untouched1.
Expanded to remove off-aroma compounds of Brett" and Smoke from wine- (wine fault
yeast Brettanomyces bruxellensis)2
To concentrate juice prior to fermentation1.
Not suitable for protein separation
1. http://www.winesecrets.com/wine-reverse-osmosis/wine-reverse-osmosis.asp
2. http://www.kenswineguide.com/wine.php?word=130
Concentration polarization
Deposition of solute on membrane.
Fouling in RO
Flux tends to decrease with time- irreversible deposition of material.
http://www.bkt21.com/membrane-and-filtration/anti-fouling-membrane/technology/
Fouling in RO
Membrane Modules:
Industrial membrane plants often require hundreds to thousands of
square metres of membrane to perform the separation required on a
useful scale.
There are several ways to economically and efficiently package
membranes to provide a large surface area for effective separation.
From an overall cost standpoint, not only is the cost of membranes per
unit area important, but also the cost of the containment vessel into
which they are mounted.
Membrane Modules:
Tubular
Spiral wound
Hollow fibre
Plate and frame
The heart of plate-frame module is the support plate.
Plate is sandwiched between two flat sheet membranes.
The plate is internally porous and provides a flow channel for
the permeate
Commercial plate-frame units are usually horizontal with the
membrane plates mounted vertically.
Tubular modules
It contains as many as 5 to 7 smaller tubes, each 0.5 to 1.0 cm in
diameter, nested inside a single larger tube.
It operate in tangential /cross-flow design
Source: http://www.egr.msu.edu/~hashsham/courses/ene806/docs/Membrane%20Filtration.pdf
Reference:
1. MEMBRANE SEPARATION PROCESSES by KAUSHIK NATH
2. Bioprocess Engineering Basic Concepts by Michael L.
Shuler and Fikret Kargi.
3. Biochemical Engineering Fundamentals by James E. Bailey
and David F. Ollis.
4. Principles of Fermentation Technology by Whittaker and
Stanbury.
5. http://www.smartmembranesolutions.co.nz/main.cfm?id
=58