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ANTIBIOTICS IN
VETERINARY PRACTICE
Submitted to: Dr. R.K. Bhardwaj, Dr. Ashok Kumar.
Submitted by: Amandeep Singh (J-12-BV-746)
5th Professional Year, B.V.Sc. & A.H.,
F.V.Sc. & A.H., SKUAST-J, R.S. Pura.
Objectives
To know about common antibiotics and their use in
clinical veterinary practice.
To know their pharmacological and toxicological
aspects.
To know about multiple drug interactions and drug-
body interactions.
Definitions
Antibiotics: It is a substance produced by a micro-
organism that at low concentration inhibit or kill other
micro-organisms.
Antibiotics
Constitutive
For Example: Inherent resistance of Enterobacteriaceae to Penicillin
G and gram positive to Polymixin B.
Acquired
It is of two types:
Chromosomal mutation to resistance: by changing target sites
(streptomycin, erythromycin), altering cell permeability
(chloramphenicol, tetracyclines), increasing production of
inactivating enzymes (-lactams).
Transferable drug resistance: (by extrachromosomal DNA) by
transduction (-lactamase gene), transformation (passage of DNA)
and conjugation (R-plasmid, responsible for MDR).
Knowledge of susceptibility of
suspected pathogen.
Knowledge of factors that
affect drug concentration at
the site of infection.
Knowledge of drug toxicity
and factors that enhance it.
Cost of treatment.
Considerations of government
regulations about drug usage.
Choice of antibiotic
Bactericidal Bacteriostatic
and shock.
In severe, acute local infections to stabilize
lysozomal enzyme release from neutrophils resulting
in tissue destruction.
In cerebral edema due to complicated meningitis.
Indications for Combined Antimicrobial Treatment
Important Notes:
Neomycin used to prevent post parturient metritis affects the fertility.
Gentamicin in mares reduces conception rates.
Tetracyclines given orally to feedlot calves causes mortality.
-lactam Antibiotics
Penam Penicillins
Discovered by Alexander Fleming in 1928.
Source: Penicillium notatum (mold)
MOA: inhibit the activity of transpeptidase and other
peptidoglycan active enzymes that are called as
penicillin binding proteins (PBPs) which are responsible
for formation of cell wall.
Have bactericidal nature on growing bacteria.
Resistance to -lactams is through production of
penicillinase enzyme that break -lactam ring of the
drug.
These are mostly effective against gram positive
bacteria.
Usual Dosages of Penicillins
Drug Route Dose Interval
Clinical Largely reserved for human medicine for P. aeruginosa and other
applications gram negatices. Cefoperaazone used for bovine coliform mastitis.
Resistance Not yet present.
Pharmacokinetics Hepatic metabolism leads to GIT problems in human subjects.
Drug interactions Group III cephalosporins are synergistic with aminoglycosides.
Toxicities and Contraindicated in horses and other herbivores with expanded
adverse effects bowel.
Pharmacokinetics In dogs and cats, mostly absorbed through GIT. With exceptions of
doxycycline and minocycline, the absorption of tetracycline is
decreased by the presence of food. They undergo enterohepatic
circulation which imparts them high half life (6-10 hours). Tissue
irritation is caused by the IM injection of the drug.
Drug interactions Synergism of tetracycline with tylosin for treating pasteurellosis,
doxycycline and rifampin or streptomycin for treating brucellosis.
Toxicities and Irritant nature cause tissue irritation, disturbance of intestinal
adverse effects flora, ability to bind with calcium and magnesium (CV effects,
deposition on teeth and bones), severe renal tubular damage.
Never use expired or degenerated preparation. In horses,
tetracyclines leads to colitis X by suppression of intestinal
microflora. They also have anti-anabolic effect which may lead to
azoturia in horses.
Species Dosage form Route Dose Interval Comments
(mg/kg) (hour)
Dogs, cats Tetracycline, oxytetracycline IV IM 10 12
Doxycycline IV 5-10 12
Horses Oxytetracycline IV 3-5 12 Slow IV
Ruminants Tetracycline, oxytetracycline IV IM 10 12-24 Slow IV
Long acting tetracycline IM 20 48
Pigs Same as ruminants IM injection
Chlortetracycline Oral 10-30 24
Clinical Applications
Cattle, Treatment of bovine pneumonias, lower respiratory tract diseases, clostridial
sheep infections and listeriosis. Oxytetracycline is drug of choice in anaplasmosis and
and Q-fever. Treatment and vaccination against bovine heart water disease by Cowdria
goats ruminatium and in treatment of keratoconjunctivitis.
Swine Atophic rhinitis and infections of lower respiratory tract.
Horses Drugs of choice for Potomac horse fever, ehrlichiosis.
Dogs, Drugs of choice for ehrlichiosis, rickettsial infections. Minocycline is affective in
cats combination with streptomycin against brucellosis. UTIs caused by P. aeruginosa.
Cats suffering from chalmydia and upper respiratory tract infections.
Poultry Chlamydiosis, CRD, infectious synovitis, fowl cholera.
Miscellaneous Antibiotics
Monensin
Ionophore antibiotic