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Pharmacokinetics Task
topic 2
the relation between
Dosage form and
Absorption
Group 3:
1. Nita Yulisa 1311011018
2. Dhena Marichy Putri 1311011022
3. Rhesty Winanda 1311011027
4. Ghea Rofifah 1311011028
5. Ayu Fadhilla Rahmi 1311011029
The drug dose and the dosage form must be chosen
to provide sufficiently high unbound drug
concentrations so that an adequate amount of
drug reaches the site of drug action (receptor).
The onset of drug action depends on the rate of the
free (unbound) drug that reaches the receptor
and produces a minimum effective concentration
(MEC) to produce a pharmacodynamic response.
(Shargel, Leon et.al, 2004)
Drug products are designed to deliver drug for
local or systemic effects. Common drug
products include liquids, tablets, capsules,
injectables, suppositories, transdermal
systems, and topical products such as creams
and ointments.
The design and formulation of drug products
requires a thorough understanding of the
biopharmaceutic principles of drug delivery.
(Shargel, Leon et.al, 2004)
Drugs are not generally given as pure chemical
drug substances but are formulated into
finished dosage forms (drug products), such as
tablets, capsules, ointments, etc, before being
administered to patients for therapy.
Formulated drug products usually include the
active drug substance and selected
ingredients (excipients ) that make up the
dosage form.
(Gibson, Mark. 2009)
a dosage form refers to the package or
container of which the drug has taken the
shape that have the ability to release the
active ingredient over an extended period
(Gibson, Mark. 2009)
The main purpose of incorporating a drug in a delivery
system is to develop a dosage form that possesses the
following attributes:
contains the labeled amount of drug in a stable form
until its expiration date
consistently delivers the drug to the general circulation
at an optimum rate and to an optimum extent
is suitable for administration through an appropriate
route
is acceptable to patients.
(Jambhekar, Sunil S and Philip J Breen. 2009)
Recognizing the fact that drug must dissolve in
the gastrointestinal (GI) fluid before it can ben
absorbed, the bioavailability of a drug would be
expected to decrease in the following order: