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PATOLOGI
Sistem
Endokrin-2
dr. Muhammad Inam Ilmiawan, M.Biomed
PSPD-FK UNTAN
2016
Parathyroid
Stimulus utama:
HIPOKALSEMIA
(9-10.5 mg/dl)
Antagonis Kalsitonin
Parathyroid hormone (PtH)-calcium feedback loop that controls calcium homeostasis.
four organsthe parathyroid glands, intestine, kidney, and bonetogether
determine the parameters of calcium homeostasis. +, positive effect; , negative
effect; 1,25 D, 1,25-dihydroxyvitamin D 3; eCf,extracellular fluid.
Gangguan paratiroid
HIPER-
Primer (umumnya adenoma; hiperplasia;
karsinoma)
Sekunder (Ca2+ rendah pada gagal ginjal)
PSEUDO-HIPO-
Resistensi organ target
Hiperparatiroid
Hiperkalsemia =
Nyeri tulang, fraktur
Batu ginjal
Konstipasi, mual, ulkus peptik, pankreatitis, batu
empedu
Depresi, letargi, kejang
Kelemahan otot, hipotonia
Poliuri dan polidipsi
QT interval pendek dan T melebar
Kalsifikasi
Hipoparatiroid
Hipokalsemia =
Neuromuskular (kesemutan, spasme otot, facial
grimacing, carpopedal spasm atau tetani)
Perubahan status mental
Parkinsonism like effects
Lens calcification/katarak
Aritmia , QT interval melebar
Gangguan pertumbuhan gigi, karies
Korteks adrenal
Glomerulosa (Salt), mineralocorticoids
ALDOSTERONE
SUGAR
SEX
STRESS
Hiperadrenalisme
(1) Hyperaldosteronism (G)
MOON BUFFALO
FACIES HUMP
Etiology:
PITUITARY ACTH INCREASE, TUMOR ACTH INCREASE
HYPERPLASIA OF CORTEX, ADENOMA OF CORTEX
CARCINOMA OF CORTEX, EXOGENOUS STEROIDS (90%)
Hyperaldosteronism
Na+ RETENTION
K+ EXCRETION
HYPERTENSION
HYPOKALEMIA
PRIMER SEKUNDER
Neoplasma korteks Penurunan perfusi ginjal
1. Acute
3. Secondary
Clinical
Progressive weakness, easy fatigability
GENETIC DISORDERS
Neoplasm
Adrenocortical adenomas
Adrenocortical carcinomas
Adrenocortical hyperplasia. The
adrenal cortex (bottom) is yellow,
thickened, and multinodular as a
result of hypertrophy and
hyperplasia of the lipid-rich zonae
fasciculata and reticularis. The top
shows a normal adrenal for
comparison
Adrenocortical adenoma. The adenoma is
distinguished from nodular hyperplasia by
its solitary, circumscribed nature. The
functional status of an adrenocortical
adenoma cannot be predicted from its
gross or microscopic appearance
Adrenal cortical adenoma. The neoplastic cells are vacuolated because of the
presence of intracytoplasmic lipid. There is mild nuclear pleomorphism.
Adrenal carcinoma. The bright yellow tumor dwarfs the kidney and compresses
the upper pole. It is largely hemorrhagic and necrotic
Adrenal carcinoma with marked anaplasia
Adrenal Medulla
Chromaffin cells neoplasms
( pheochromocytomas)
Neuronal neoplasms
( neuroblastoma, ganglion cell
tumor)
Pheochromocytoma
"rule of 10s":
10% several familial syndromes
10% extra-adrenal, paraganglioma
10% bilateral
10% biologically malignant
Hypertension
Tachycardia, palpitations, headache, sweating, tremor
Pheochromocytoma. The
tumor is enclosed within an
attenuated cortex and
demonstrates areas of
hemorrhage. The comma-
shaped residual adrenal is
seen below
Pheochromocytoma, demonstrating characteristic nests of cells ("Zellballen") with
abundant cytoplasm.
Neuroblastoma
MEN Multiple Endocrine Neoplasia Syndromes
Proliferative lesions (hyperplasias, adenomas, and carcinomas)
Multiple endocrine organs (in one organ, the tumors are often
multifocal)
Hyper- Parathyroid-ism
MEN-2B: NO hyperparathyroidism,
ganglioneuromas of mucosal sites (gastrointestinal
tract, lips, tongue)
ENDOCRINE
PANCREAS
Immunoperoxidase staining shows a dark reaction product for insulin in
cells (A), glucagon in cells (B), and somatostatin in cells (C). D, Electron
micrograph of a cell shows the characteristic membrane-bound granules,
each containing a dense, often rectangular core and distinct halo. E,
Portions of an cell (left) and a cell (right) also show granules, but with
closely apportioned membranes.
Diagnosis
Glucosa acak >200
Atau
Atau
Infections
ATHEROSCLEROSIS
ATHEROSCLEROSIS
RETINOPATHY in Dm
Microaneurysms,
Areas of hemorrhage,
IS
Nodular
glomerulosclerosis
NEPHROPATHY
NEPHROSCLEROSIS
NEPHROPATHY
GBM thickening
NEPHROPATHY
Diffuse
Mesangial
Sclerosis
INFECTIONS in Dm
SKIN
TUBERCULOSIS
PNEUMONIA
PYELONEPHRITIS
CANDIDA
NEOPLASMS of the Endocrine
Pancreas
Islet cell tumors
Beta cells INSULINOMAS (NOT rare)
Alpha cells GLUCAGONOMAS (rare)
Delta cells SOMATOSTATINOMAS (rare)