EVALUATION OF THE PATIENTS

DIAGNOSED WITH STEVENS

JOHNSON SYNDROME AND TOXIC
EPIDERMAL NECROLYSIS:
A SINGLE CENTER EXPERIENCE

kr eki, Yakup Cantez, Nihat Sapan

Division of Pediatric Allergy, Department of Pediatrics, Uluda University School of Medicine, Bursa, Turkey
Member of Group
Wahyu Widyastuti Ratnasari 1513010002
Elsandi Fiqri Firdaus 1513010009
Deby Wicaksono S 1513010023
Enrika Tunjung Puspita 1513010024
RD Selma Rachmawati B 1513010030
Prima Ufiyantama A S 1513010034
Rasi Irfan Asany 1513010036
Paramita Anindya Hapsari 1513010042
Dipa Andhika Harnolis 1513010046
Cory Dwi Rizki Octavianti 1513010044
Stevens Johnson syndrome (SJS) and toxic epidermal
necrolysis (TEN) are life-threatening, delayed type
hypersensitivity reactions.
Stevens Johnson syndrome and toxic epidermal
necrolysis are severe acute mucocutaneous diseases.
Aim
In this study, it was aimed to evaluate the clinical
properties, etiologic factors, laboratory data,
therapies used and treatment responses in the
patients who were followed up with a diagnosis of
SJS, TEN and SJS/TEN overlap in the last 5 years in
author clinic.
Background

SJS and TEN delayed type hypersensitivity

Prevalence 1,2-6 x 106 and 0,4-1,2 x 106
Pathogenesis
Defect drug bioactivation

N-acetylation capacity

Presence of certain HLA Group

Method

Materials 11 patients
Methods
Clinical findings

Laboratory test

Response to treatment
Result
Female 54.5% (n=6)

Median age: 4 years

Male 45.4% (n=5)

-2 SJS
Diagnosed - 4 TEN
- 5 SJS/TEN

Median period of drug usage

10 days
Result

before presentation

Median time for recovery of

38 days
the lesions

Median period of
14 days
hospitalization

Maculopapular eruptions,
mucositis in the mouth and all patient
eye

Formation of vesicle and/or

bulla and epi- 10 patients
dermal separation
Result
Result
Result
Discussion
The initial symptoms The predormal
There is other generally begin 4- period generally
etiology association 14 days after changes between 1
with SJS/TEN medication, prolong and 14 days
up to 3-6 weeks

In this study : In this study : 10 In this study : 2

Herpes virus days days
specific IgM (+)
Discussion

No consensus on a definite treatment method

for SJS/TEN

General treatment approach

Systemic steroids
IVIG
Cyclosporine *
Conclusion

SJS/TEN rarely in the childhood, but they are serious skin disease with
high morbidity and mortality rates

General treatment lowering morbidity and mortality rates

Early diagnosis and treatment informed about delayed type

hypersensitivity
Strength

Informed consent was obtained

Data was complete (Table 1)

Weakness

The study held in a single center

The number of patient too small

Suggestion

More center for more data variation

Establish best treatment for SJS/TENT

Critical Appraisal
Thank you