PATOGENESIS PERUBAHAN

JARINGAN AKIBAT INFEKSI

ORGANISME NON SPESIFIK
DR. FARADILLA ANWAR SPPA
 BENTUK-BENTUK PERUBAHAN JARINGAN AKIBAT
INFEKSI
THIS LONGER-TERM INFLAMMATION PROCESS MAY BE IDENTIFIED
BY DISTINCTIVE HISTOLOGIC FINDINGS THAT OCCUR IN THESE
CHRONIC FORMS OF INFLAMMATION:
CHRONIC NONSUPPURATIVE INFLAMMATION;
CHRONIC SUPPURATIVE INFLAMMATION;
GRANULOMATOUS INFLAMMATION.
 RADANG KRONIK NON SUPPURATIF

PATHOGENETIC FACTORS INCLUDE :

(A) AN IMMUNE INFLAMMATORY REACTION WITH CYTOTOXIC LYMPHOCYTES AND/OR
ANTIGEN-ANTIBODY REACTION AND
(B) NOXIOUS ENVIRONMENTAL AGENTS AND CERTAIN PATHOGENS.
ASSOCIATED DISORDER : CHRONIC BRONCHITIS
Radang kronik pada paru : * pengumpulan radang kronik limfosit, kerusakan parenkim (alveoli normal
digantikan selapis epitel kuboid (kepala panah), dan terjadi fibrosis (tanda panah)
Granulating Inflammations
General definition: Chronic inflammations characterized
by formation of new capillary-rich,
absorptive mesenchyma (granulation tissue).
General histologic findings: The following threelayer
structure of the inflammatory granulation
tissue is common to all chronic granulating inflammations:
Resorption zone ( A1, B1): This innermost
zone borders directly on the necrotic material
and primarily consists of phagocytic
histiocytes. These cells store the poorly soluble
fat in lysosomal vacuoles and are
known as foam cells because of the foamy
vacuolar appearance of their cytoplasm.
Granulation zone ( A2, B2): This zone consists
of granulation tissue rich in capillaries
and fibroblasts. The tissue has a resorptive
and reparative function; branching capillaries
have the superficial appearance of
granules (hence the term granulation tissue).
Mature connective tissue zone ( A3): This
oldest and outermost layer of tissue consists
of granulation tissue that has matured to
highly fibrous connective tissue, giving it
a high degree of mechanical strength.
Granulomatous Inflammations
General definition: Chronic
inflammation whose
primary characteristic is large
nodule of inflammatory cells,
Often measuring several
millimeters.
The focal concentration of cells
of the macrophage system
involved informing the
granuloma
(macrophages, epithelioid cells,
and multinucleated
giant cells) varies among
individual inflammations.
As a result, a granuloma may
be
sharply demarcated or diffuse
and ill-defined
 Peradangan granulomatous terdiri dari :

Epithelioid granulomas
Definition: Sharply demarcated
nodules consisting
largely of densely grouped,
specialized
macrophages (epithelioid cells).
Pathogenesis and morphology: Some
of these
granulomas are caused by relatively
toxic substances
such as mycobacterial components
(tuberculin).
Only a few macrophages in the
granuloma
contain the irritant.
Epithelioid granulomas include:
Sarcoidal granulomas and
Tubercular granulomas.
Histiocytic Granulomas
Definition: Ill-defined nodular
accumulations of
primarily phagocytic histiocytes (foreign-
body
granuloma).
Pathogenesis and morphology: These
granulomas
primarily consist of histiocytes and are
caused by minimally toxic foreign
substances
such as urate or substances not recognized
as
endogenous such as collagen covered by
immune
complex. Nearly all the histiocytes in
them (macrophages) are covered with
irritant
or are involved in phagocytizing it.
Histiocytic granulomas include:
Rheumatic granuloma;
Rheumatoid granuloma;
Foreign-body granuloma.
Foreign-Body Granuloma
Definition: Histiocytic granuloma
surrounding
material that the body can
break down only
with difficulty or not at all and
that has lodged
in or been released into tissue.
Substances eliciting foreign-
body reactions
may be crystalline or metallic,
or they may be
polymerized substances.