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The Biology
of Mind
PowerPoint Presentation
by Jim Foley
3
Searching for the self by studying the body
Phrenology
Phrenology
(developed by Franz Gall in
the early 1800s):
the study of bumps on the
skull and their relationship
to mental abilities and
character traits
The synapse is
also known as the
synaptic
junction or
synaptic gap.
Neurotransmitters
Neurotransmitters
are chemicals
used to send a
signal across the
synaptic gap.
Reuptake:
Recycling Neurotransmitters [NTs]
Reuptake:
After the neurotransmitters
stimulate the receptors on
the receiving neuron, the
chemicals are taken back up
into the sending neuron to
be used again.
Neural Communication:
Seeing all the Steps Together
Roles of Different Neurotransmitters
Some Neurotransmitters and Their Functions
Neurotransmitter Function Problems Caused by Imbalances
Serotonin Affects mood, hunger, Undersupply linked to depression;
sleep, and arousal some antidepressant drugs raise
serotonin levels
Dopamine Influences movement, Oversupply linked to schizophrenia;
learning, attention, and undersupply linked to tremors and
emotion decreased mobility in Parkinsons
disease and ADHD
Acetylcholine Enables muscle action, ACh-producing neurons deteriorate as
(ACh) learning, and memory Alzheimers disease progresses
Norepinephrine Helps control alertness Undersupply can depress mood and
and arousal cause ADHD-like attention problems
GABA (gamma- A major inhibitory Undersupply linked to seizures,
aminobutyric acid neurotransmitter tremors, and insomnia
Glutamate A major excitatory Oversupply can overstimulate the brain,
neurotransmitter; producing migraines or seizures; this is
involved in memory why some people avoid MSG
(monosodium glutamate) in food
Serotonin Dopamine
pathways pathways
Networks of neurons that Networks of neurons that
communicate with serotonin communicate with dopamine are
help regulate mood. involved in focusing attention
and controlling movement.
Hearing the message
How Neurotransmitters Activate
Receptors
When the
key fits,
the site is
opened.
Keys that almost fit:
Agonist and Antagonist Molecules
Nerves consist of
neural cables
containing many
axons.
Nerves are part of
the peripheral
nervous system and
connect muscles,
glands, and sense
organs to the
central nervous
system.
More Parts of the Nervous System
The Peripheral Nervous System
The
Autonomic
Nervous
System:
The sympathetic
NS arouses
(fight-or-flight)
The
parasympathetic
NS calms
(rest and digest)
The Central Nervous System
This is an example
of a reflex action.
The Endocrine System
Adrenal Glands
1. The sympathetic
fight or flight
nervous system
responds to stress
by sending a
message to
Pancreas adrenal glands to
release the
hormones listed
above.
2. Effect: increased
heart rate, blood
pressure, and
blood sugar. These
provide ENERGY
for the fight or
flight!
The Pituitary Gland
The pituitary gland is the
master gland of the
endocrine system.
It is controlled through
the nervous system by the
nearby brain area--the
hypothalamus.
Pituitary gland
The pituitary gland
produces hormones that
regulate other glands
such as the thyroid.
It also produces growth
hormone (especially
during sleep) and
oxytocin, the bonding
hormone.
The Brain
What well discuss:
how we learn about the brain
the life-sustaining inner parts of the
brain: the brainstem and limbic system
the outer, wrinkled bark: the cortex
left, right, and split brains
Questions about parts of the brain:
Do you think that the brain is the Is it possible to
sum of its parts, or is the brain understand the brain?
actually about the way they are
connected? If the human brain were
What do you think might happen so simple that we could
if a particular area of the brain understand it, we would
was stimulated? be so simple that we
couldnt.
What do you think might happen Emerson M. Pugh
if a particular area of the brain
was damaged or not working but we can try.
well?
Investigating the Strategies for finding out
what is different about the
Brain and Mind: mind when part of the
brain isnt working
How did we move beyond normally:
phrenology?
How did we get inside the case studies of accidents
skull and under the (e.g. Phineas Gage)
bumps? case studies of split-brain
by finding what happens patients (corpus callosum
when part of the brain is cut to stop seizures)
damaged or otherwise lesioning brain parts in
unable to work properly animals to find out what
by looking at the happens
structure and activity of chemically numbing,
the brain: CAT, MRI, magnetically deactivating,
fMRI, and PET scans or electrically stimulating
parts of the brain
Studying cases of brain damage
When a stroke or injury damages part of the brain, we
have a chance to see the impact on the mind.
Intentional brain damage:
Lesions (surgical
destruction of brain
tissue)
performed on animals
has yielded some
insights, especially
about less complex
brain structures
no longer necessary, as
we now can chemically
or magnetically
deactivate brain areas
to get similar
information
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Split-Brain Patients
Split = surgery in
which the
connection between
the brain
hemispheres is cut
in order to end
severe full-brain
seizures
Study of split-brain
patients has yielded
insights discussed at
the end of the
chapter
We can stimulate parts of the brain
to see what happens
Parts of the brain, and even neurons, can
be stimulated electrically, chemically, or
magnetically.
This can result in behaviors such as
giggling, head turning, or simulated vivid
recall.
Researchers can see which neurons or
neural networks fire in conjunction with
certain mental experiences, and even
specific concepts.
Monitoring activity in the brain
Tools to read electrical, metabolic, and magnetic
activity in the brain:
MRI: magnetic
fMRI: functional MRI
resonance imaging
An EEG (electroencephalogram)
EEG: is a recording of the electrical
electroencephalogram waves sweeping across the
brains surface.
An EEG is useful in studying
seizures and sleep.
37
The PET scan allows us to see what
PET: positron emission
part of the brain is active by
tomography tracing where a radioactive form
of glucose goes while the brain
performs a given task.
MRI: magnetic
fMRI: functional MRI
resonance imaging
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Areas of the brain and their functions
Thalamus
Reticular Formation
Cerebellum
Limbic System
The Brainstem:
Pons and Medulla
The Base of the
Brainstem:
The Medulla
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Functions of the Brain:
The Motor and Sensory Strips
Output: Motor Input: Sensory
cortex (Left cortex (Left
hemisphere hemisphere
section section receives
controls the input from the
bodys right bodys right side)
side)
Axons Axons
receiving motor sending
signals FROM sensory
the cortex information
TO the cortex
Using our knowledge of functions:
Brain-computer interfaces
and neural prosthetics
Here, a robotic arm is
operated through
controls embedded in
the motor strip of the
cortex.
We may soon be able to
use computers to
translate neural inputs
into more commands
and words than simply
grabbing food.
Sensory Functions of the Cortex
To end severe
whole-brain
seizures, some
people have had
surgery to cut the
corpus callosum,
a band of axons
connecting the Researchers have studied the
hemispheres. impact of this surgery on
patients functioning.
Separating the Hemispheres:
Factors to Keep in Mind
71
The divided brain in action
Talent: people
are able to
follow two
instructions and
draw two
different shapes
simultaneously
Drawback:
people can be
frustrated that
the right and left
sides do
different things
The Future of Brain Research
Can these questions be answered?
Is every part of the minds functioning going to
be found someday on some brain scan?
If so, have we found the mind, or is that still
something separate from the brain?
Chapter 2
The Biology
of Mind
PowerPoint
Presentation
by Jim Foley