Vous êtes sur la page 1sur 4

Given the data in Table below, calculate elimination rate and excretion rate after an IV

Bolus dose of 400 mg. Find the equation of the excretion profile. Assume a linear one
compartment model.

Amount of
Volume of Rate of
Time duration Concentrati drug Midpoint
Urine excretion,
Interval of interval on in Urine, excreted in time, t*
Excreted, dDu/dt
(hr) (hr) Cu (µg/ml) urin, Du (hr)
Vu (ml) (mg/jam)
(mg)

0-1 1 91 805 73,255 0,5 73,26


1-2 1 99 539 53,361 1,5 53,36
2-4 2 206 324 66,744 3 33,37
4-6 2 194 181 35,114 5 17,56
6-9 3 no sample 7,5
9-12 3 577 16 9,232 10,5 3,08
12-24 12 1127 5 5,635 18 0,47
10,0
90,0 Ke.DB0= 84 mg/jam Ke.400 mg= 84 mg/jam
Given the data in Table below, 80,0
70,0 x Ke = 84 mg/jam / 400 mg
Ke = 0,21 jam-1
60,0
calculate elimination rate and 50,0
x

excretion rate after an IV Bolus 40,0


x
dose of 400 mg. Find the 30,0 t1/2 =(7,25 – 4,75) jam
t1/2 = 2,5 jam
equation of the excretion
20,0
profile. Assume a linear one x

Laju ekskresi dDu/dt (mg/jam)


compartment model. K = 0,693/t1/2
10,0 K = 0,693/2,5 jam-1
9,0 K = 0,277 jam-1
8,0
7,0
6,0
Rate of 5,0
Time Midpoint
excretion, 4,0
Interval time, t* x
dDu/dt 3,0
(hr) (hr)
(mg/jam) 2,0

0-1 0,5 73,26


1-2 1,5 53,36 1,0
0,9
0,8
0,7
2-4 3 33,37 0,6
0,5 x
4-6 5 17,56 0,4

6-9 7,5 0,3

9-12 10,5 3,08 0,2

12-24 18 0,47
t (jam)
0,1
0 1 2 3 4 4,75
5 6 7,25
7 8 9 10 11 12 13 14 15 16 17
90 100
Laju ekskresi urin, dDu/dt (mg/jam)
80
dDu/dt = 79,14e-0,29t dDu/dt = 79,14e-0,29t

Laju ekskresi urin, dDu/dt (mg/jam)


70
60
10
50
40
30
20 1
0 5 10 15 20
10
0
0 5 10 15 20
0.1
Waktu, t (jam) Waktu, t (jam)

Plot linier Plot semilogaritmik

Ke.DB0= 79,14 mg/jam


Ke.400 mg= 79,14 mg/jam
Ke = 79,14 mg/jam / 400 mg
Ke = 0,198 jam-1
Given the data in Table below, calculate elimination rate and excretion rate after an IV
Bolus dose of 400 mg. Find the equation of the excretion profile. Assume a linear one
compartment model.

Amount of
Rate of
duration of drug
Midpoint excretion,
interval Volume of Concentrat excreted in
time, t* (hr) dDu/dt
Time (hr) Urine ion in urin, Du
(mg/jam)
Interval Excreted Urine (mg)
(hr) (ml) (µg/ml)
0-1 1 65 480 31,20 0,5 31,20
1-2 1 64 390 24,96 1,5 24,96
2-4 2 121 315 38,12 3 19,06
4-6 2 130 205 26,65 5 13,33
6-9 3 no sample 7,5

9 - 12 3 175 75 13,13 10,5 4,38


12 - 24 12 750 25 18,75 18 1,56

Vous aimerez peut-être aussi