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Bolus dose of 400 mg. Find the equation of the excretion profile. Assume a linear one
compartment model.
Amount of
Volume of Rate of
Time duration Concentrati drug Midpoint
Urine excretion,
Interval of interval on in Urine, excreted in time, t*
Excreted, dDu/dt
(hr) (hr) Cu (µg/ml) urin, Du (hr)
Vu (ml) (mg/jam)
(mg)
12-24 18 0,47
t (jam)
0,1
0 1 2 3 4 4,75
5 6 7,25
7 8 9 10 11 12 13 14 15 16 17
90 100
Laju ekskresi urin, dDu/dt (mg/jam)
80
dDu/dt = 79,14e-0,29t dDu/dt = 79,14e-0,29t
Amount of
Rate of
duration of drug
Midpoint excretion,
interval Volume of Concentrat excreted in
time, t* (hr) dDu/dt
Time (hr) Urine ion in urin, Du
(mg/jam)
Interval Excreted Urine (mg)
(hr) (ml) (µg/ml)
0-1 1 65 480 31,20 0,5 31,20
1-2 1 64 390 24,96 1,5 24,96
2-4 2 121 315 38,12 3 19,06
4-6 2 130 205 26,65 5 13,33
6-9 3 no sample 7,5