Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

GFR- REGULATION

 WHY IT SHOULD REMAIN CONSTANT?

 WHICH FEEDBACK MECHANISM

REGULATE GFR?
 RELATION WITH BLOOD PRESSURE.
 IMP PARAMETER TO ASSESS RENAL
FUNCTION.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

GFR

 The amount of the glomerular filtrate

by all the nephrons of both the
kidneys in a one minute is called GFR
 GFR = filtration fraction x RBF
 In the average human adult, the GFR
is about 125 ml / min. or 180 L / day
 Filtration fraction – the fraction of the
renal plasma which becomes the
filtrate
 Filtration fraction = GFR / RBF
1/16/2018 Renal physiology 3
 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Autoregulation of
GFR.
Afferent arteriole
vasodilatation

Renin angiotensin
mechanism

Role of macula densa

cells.

Tubuloglomerular
feedback

Constant G.F.R.

Upto b.p. range 80-180

 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

GFR AND RENAL BLOOD FLOW RUN PARRELEL

Renal physiology (Dr. Ashok

Solanki) 5
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Renal physiology (Dr. Ashok Solanki)

6
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

7
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

FACTORS AFFECTING GFR

8
 Changes in renal blood flow
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.


 Changes in glomerular capillary hydrostatic pressure

 Changes in systemic blood pressure

 Afferent or efferent arteriolar constriction

 Changes in hydrostatic pressure in Bowman's capsule

 Ureteral obstruction

 Edema of kidney inside tight renal capsule

Changes in concentration of plasma proteins: dehydration,

hypoproteinemia, etc (minor factors)

 Changes in Kf

 Changes in glomerular capillary permeability

 Changes in effective filtration surface area

9