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Signal Transduction
outside
GPCR plasma
The a subunit of membrane
outside
GPCR plasma
membrane
agga cytosol
AC
GDP bbGTP
outside
GPCR plasma
membrane
agga cytosol
AC
GDP bbGTP
outside
GPCR plasma
membrane
agga cytosol
AC
GDP bbGTP
outside
GPCR plasma
membrane
agga cytosol
AC
GDP bbGTP
GTP hydrolysis N
NH
H
H O O O O N N NH2
O P O P O P O CH2
O
O O O H H
H H
OH OH
PDB 1GP2
GDP
GEF GAP
GTP Pi
protein-GDP (inactive)
GDP
GEF GAP
GEFs, Guanine Nucleotide
GTP Pi
Exchange Factors, promote
GDP/GTP exchange. protein-GDP (inactive)
O H2C O C R2
R1 C O CH O
H2C O P O
O H
1 6
OH OH
H OH
2 H 5
OH
phosphatidyl- H H
3 4
inositol H OH
O H2C O C R2
R1 C O CH O
H2C O P O
O H
1 6
OH OPO32
H OH
2 OH H 5
H H
PIP2 3 4
phosphatidylinositol- H OPO32
4,5-bisphosphate
++
endoplasmic
View an Ca reticulum
animation.
Ca++-ATPase
ATP ++ ADP + Pi
Ca
OH OPO32 OH OH
H OH H OH
OH H OH H + 3 Pi
(3 steps)
H H H H
H OPO32 H OH
IP3 inositol
O H2C O C R2
R1 C O CH O
H2C O P O
O H
1 6
OH OH
phosphatidyl- H OH
inositol- 2
OPO32 H
5
3-phosphate H H
3 4
H OH
O H2C O C R2
R1 C O CH O
H2C O P O
O H
PI-3-P, PI-3,4-P2, 1 6
OH OH
PI-3,4,5-P3, and phosphatidyl- H OH
inositol- 2
OPO32
H
5
PI-4,5-P2 have 3-phosphate H H
signaling roles. 3 4
H OH