Curriculum Vitae

SHIGEO HORIE, M.D.

Date of Birth: Sept. 20, 1960

Education:

Post graduate training and Present Position

EDUCATION
1979-1981 College of Arts and Sciences, The University of Tokyo,Tokyo, Japan
1981-1985 Faculty of Medicine, The University of Tokyo

POST GRADUATE TRAINING AND PRESENT POSITION:

1985 Residency in Urology; University of Tokyo Hospital and affiliated hospitals
1988 Instructor, Department of Urology, Faculty of Medicine, University of Tokyo
1988 Research fellow, Division of Nephrology,The University of Texas, Southwestern
Medical Center at Dallas, Dallas, TX
1989 Clinical fellow, Transplant Service, Parkland Memorial Hospital, Dallas, TX.
1995 Staff Surgeon, National Cancer Center Hospital
1998 Assistant Professor, Department of Urology, The University of Tokyo
2002 Associate Professor, Department of Urology, Kyorin University
2003 Professor and Chairman, Department of Urology, TeikyoUniversity
2012 Professor and Chairman, Department of Urology, Juntendo University Graduate
School of Medicine
LICENSES :
National Medical Licensure: 1985
ECFMG: permanent certification: 1989
Institutional license for the practice of medicine. The State of Texas, 1990

Award:
1995 JUA award for the excellence in research, the Japanese Urological Association
1991 First Prize in Research, National Kidney Foundation/American Society of
Nephrology Fellowship Program
2015 Best Professor, Juntendo University Faculty of Medicine
Original articles
1. HigashiharaE, HorieS, Takeuchi T, NutaharaK, AsoY: Long-term consequence of nephrectomy. The Journal of
Urology 143: 239-243, 1990
2. HigashiharaE, HorieS, TakeuchiT, KameyamaS, AsakageY, HosahaY, HommaY, MinowadaS, AsoY: Laser
ureterolithotripsy with combined rigid and flexible ureterorenoscopy. The Journal of Urology 143: 273-274, 1990
3. HorieS, MoeO, TejedorA, AlpernRJ :Preincubation in acid medium increases Na/H antiporter activity in cultured
renal proximal tubule cells. Proceedingsof the National Academy of Sciences of the United States of America.
87:4742-4745, 1990
4. MoeO, MillerRT, HorieS, CanoA, PreisigPA, AlpernRJ: Differential regulation of Na/H antiporter by acid in renal
epithelial cells and fibroblasts. The Journal of Clinical Investigation 88:1703-1708, 1991
5. AlpernRJ, HorieS, MoeO, TejedorA, MillerRT, PreisigPA : Chronic adaptations in proximal tubular H/HCO3
transporters. Kidney International 33: S29-32, 1991
6. HorieS, MoeO, MillerRT, AlpernRJ: Long-term activation of protein kinase C causes chronic Na/H antiporter
stimulation in cultured proximal tubule cells. The Journal of Clinical Investigation 89: 365-372, 1992
7. BenjaminI, HorieS, GreenbergML, AlpernRJ, WilliamsRS: Induction of stress proteins cultured myogenic cells.
Molecular signals for the activation of heat shock transcription factor during ischemia. The Journal of Clinical
Investigation 89:1685-1689, 1992
8. HorieS, MoeO, YamajiY, CanoA, MillerRT, AlpernRJ: Role of protein kinase C and transcription factor AP-1 in the
acid-induced increase in Na/H antiporter activity. Proceedingsof the National Academy of Sciences of the United
States of America. 89:5236-5240, 1992
9. AlpernRJ, YamajiY, CanoA, HorieS, MillerRT, MoeOW, PreisigPA: Chronic regulation of the Na/H antiporter.The
Journal of Laboratory and Clinical Medicine 122: 137-140, 1993
10. HigashiharaE, TanakaY, HorieS, ArugaS, NutaharaK, MiniwadaS, AsoY: Laparoscopic adrenalectomy: the initial 3
cases. The Journal of Urology 149: 973-976, 1993
11. HorieS, HigashiharaE, NutaharaK, Mikami, OkuboA, KanoM, KawabeK:Mediation of renal cyst formation by
hepatocyte growth factor. Lancet 344: 789-791, 1994
Original articles
12. Santa T, Nishihara K, Horie S, Kotaki H, Sawada Y, Kawabe K, Iga T: Decreased cyclosporinA absorption after
treatment with GoLytely lavage solution in rats. The Journal of Pharmacy and Pharmacology 46:606-607, 1994
13. Santa T, Nishihara K, Horie S, Kotaki H, Yamamoto K, Shibuya F, Ito K, Sawada Y, Kawabe K, Iga T. Decreased
cyclosporine absorption after treatment with GoLytely lavage solution in a kidney transplant patient. The Annals of
Pharmacotherapy28:963-964, 1994
14. WangH, KuwataS, JujiT, YanagisawaM, TokunagaK, HorieS, HigashiharaE, KurokawaK, YoshikuraH, ShibataY: Ethnic
difference in allele frequencies of two microsatellite markers closely linked to the locus for polycystic kidney disease
1 (PKD1). Human Heredity 45: 84-89, 1995
15. Moriyama N, Kurimoto S, Horie S, Nasu K, Tanaka T, Yano K, Hirano H, Tsujimoto G, Kawabe K. Detection of alpha
1-adrenoceptor subtypes in human hypertrophied prostate by in situ hybridization.The Histochemical Journal 28:283-
288, 1996.
16. HorieS, KanoM, Higashihara E, MoriyamaN, TanakaE, HiroseA, KakizoeT, KawabeK : Expression of Fas in renal cell
carcinoma. Japanese Journal of Clinical Oncology 27:384-388, 1997
17. Tobisu K, Kanai Y, Sakamoto M, Fujimoto H, Doi N, Horie S, Kakizoe T :Involvement of the anterior urethra in male
patients with transitional cell-carcinoma of the bladder undergoing radical cystectomy with simultaneous
urethrectomy. Japanese Journal of Clinical Oncology 27:406-409, 1997
18. Kurimoto S, Moriyama N, Horie S, Sakai M, Kameyama S, Akimoto Y, Hirano H, Kawabe K : Co-expression of
hepatocyte growth factor and its receptor in human prostate cancer. The Histochemical Journal 30:27-32, 1998
Horie S, Tobisu K, Fujimoto H, Doi N, Kakizoe T : Urinary incontinence following non nerve-spared radical
prostatectomy with neoadjuvant androgen deprivation. Urology 53:561-567, 1999
19. Horie S, Aruga S, Kawamata S, Okui N, Kakizoe T, Kitamura T : Biological role of HGF/MET pathway in renal cell
carcinoma. The Journal of Urology 161:990-997, 1999
20. Muto S, Horie S, Takahashi S, Tomita K, and Kitamura T : Genetic and epigenetic alterations in normal bladder
epithelium in patients with metachronous bladder cancer. Cancer Research 60:4021-4025, 2000
21. Nishimatsu H, Hirata Y, Hayakawa H, Nagata D, Satonaka H, Suzuki E, Horie S, Takeuchi T, Ohta N, Homma Y,
Minowada S, Nagai R, Kawabe K, Kitamura T :Effects of intracavernous administration of adrenomedullin on erectile
function in rats. Peptides 22:1913-1918, 2001
AWARD:
1995 JUA award for the excellence in research, the Japanese Urological Association
1991 First Prize in Research, National Kidney Foundation/American Society of
Nephrology Fellowship Program