Vous êtes sur la page 1sur 19

Anesthesia Secrets:

Intern 張雅婷
 The passage of material from the pharynx into
the trachea.

 Material origin:
 Mouth
 Nose
 Stomach
 Esophagus
 Incidence of significant aspiration:1/10,000 anesthetics.
(Children’s anesthetics: 2/10,000 anesthetics)

 The average hospital stay after aspiration: 21 days, most

in intensive care unit.

 Complications: bronchospasm, pneumonia, and acute

respiratory distress syndrome, lung abscess, and

 Average mortality rate is 5%.

Aspiration syndromes
 Aspiration of gastric acid causes a chemical
pneumonitis which has also been called
Mendelson syndrome.

 Aspiration of bacteria from oral and pharyngeal

areas causes aspiration pneumonia.

 Aspiration of oil (eg. mineral oil or vegetable oil)

causes exogenous lipoid pneumonia, an unusual
form of pneumonia.

 Aspiration of a foreign body may cause an acute

respiratory emergency.
 Aspiration pneumonitis describes the initial
inflammatory response after aspiration.

 Aspiration pneumonia describes the

consolidation along with the inflammation.
Risk factors
 Extremes of age

 Type of surgery(most common in cases of esophageal, upper

abdominal, or emergency laparotomy surgery)

 Inappropriate recent meal

 Delayed gastric emptying and/or decreased lower

esophageal sphincter tone (diabetes, gastric outlet
obstruction, hiatal hernia)

 Medications (e.g., narcotics, anticholinergics)

 Trauma
Risk factors
 Pregnancy

 Pain and stress

 Depressed level of consciousness

 Morbid obesity

 Difficult airway

 Neuromuscular disease (impaired ability to protect the


 Esophageal disease (e.g., scleroderma, achalasia,

diverticulum, Zenker diverticulum)
 Empty stomach before anesthetic induction:

1. Adequate fasting period.

2. Gastrokinetic medications such as metoclopramide have

been thought to be of benefit because they enhance
gastric emptying, but no good data support this belief.
 Increase gastric pH:

1. Nonparticulate antacids: sodium citrate and histamine-2 (H2)

receptor antagonists, either of which decreases acid

2. H2 antagonists: cimetidine, ranitidine, and famotidine.

3. To be effective at induction, H2 blockers must be

administered 2 to 3 hours before the procedure.

4. The use of proton pump inhibitors in place of, or in concert

with, H2 antagonists has not proven to be more efficacious.
H2 blocker
1. Cimetidine has significant side-effect: hypotension, heart
block, central nervous system dysfunction, decreased hepatic
blood flow, and significant retardation of the metabolism of
many drugs.

2. Ranitidine: a newer H2 antagonist, is much less likely to cause

side effects. Only a few cases of central nervous system
dysfunction and heart block have been reported.

3. Famotidine is equally as potent as cimetidine and ranitidine

and has no significant side effects.
Management of difficult
airway pt. and those at high
risk of aspiration
 regional anesthetic
 rapid sequence induction with cricoid pressure is preferred
when a general anesthetic is needed.
 Patients with difficult airways may require awake
placement of an endotracheal tube to allow protection of
the airway from aspiration.
 Patient comfort is aided by the judicious use of sedation
and topical local anesthetic. Oversedation and
topicalization of the airway may make the patient less able
to protect the airway.
 Endotracheal intubation does not guarantee that no
aspiration will occur. Material may still slip past a deflated or
partially deflated cuff.
Rapid sequence induction
 RSI is the preferred method of endotracheal tube intubation in
the emergency department.

 Results in rapid unconsciousness (induction) and

neuromuscular blockade (paralysis).

 This is important in patients who have not fasted and because

of this are at much greater risk for vomiting and aspiration.

 The goal of RSI is to intubate the trachea without having to use

bag-valve-mask ventilation.
Acidic aspirates
 pH less than 2.5 and volumes of more than 0.4 ml/kg

 Alveolar-capillary breakdown, resulting in interstitial edema,

intraalveolar hemorrhage, atelectasis, and increased airway

 Hypoxia is common. Although such changes usually start

within minutes of the initiating event, they may worsen over
a period of hours.

 The first phase of the response is direct reaction of the lung

to acid— hence the name chemical pneumonitis. The
second phase, which occurs hours later, is caused by a
leukocyte or inflammatory response to the original damage
and may lead to respiratory failure.
Aspiration of nonacidic fluid
 Destroys surfactant, causing alveolar collapse and
 Hypoxia is common.
 The destruction of lung architecture and the late
inflammatory response are not as great as in acid
Aspiration of particulate
food matter
 Aspiration of particulate food matter causes both physical
obstruction of the airway and a later inflammatory response.

 Alternating areas of atelectasis and hyperexpansion may


 Patients may have hypoxia and hypercapnia caused by

physical obstruction of airflow.

 If acid is mixed with the particulate matter, damage is often

greater and the clinical picture worse.
clinical signs and symptoms
after aspiration
 Fever occurs in over 90% of aspiration cases, with tachypnea
and rales in at least 70%.

 Cough, cyanosis, and wheezing occur in 30% to 40% of cases.

 Aspiration may occur silently—without the anesthesiologist’s

knowledge—during anesthesia.

 Radiographic changes may take hours to occur and may be

negative, especially if radiographic images are taken soon
after an event.

 The patient who shows none of the previously mentioned signs

or symptoms and has no increased oxygen requirement at the
end of 2 hours should recover completely.
mostly supportive care
 Chest radiograph and hours of observation.

 Immediate suctioning

 Supplemental oxygen and ventilatory support should be

initiated if respiratory failure is a problem.

 Patients with respiratory failure often demonstrate atelectasis

with alveolar collapse and may respond to positive end-
expiratory pressure.

 Patients with particulate aspirate may need bronchoscopy to

remove large obstructing pieces.
 Antibiotics should not be administered unless there is a high
likelihood that gram-negative or anaerobic organisms have
been aspirated.
 Corticosteroids have not been shown to be helpful in human
 Lavaging the trachea with normal saline or sodium
bicarbonate after aspiration has not been shown to be helpful
and may actually worsen the patient’s status.
 More aggressive treatments of severe aspiration usually occur
in the critical care setting. Surfactant installation, high-
frequency oscillatory ventilation, and prone positioning have
all shown some promise for certain patients with severe