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Exon Shuffling
Computational Methods in Genomics
Bioinformatics
• The field used in
biochemistry to discover
the function of an
unknown gene, such as a
human disease gene,
that can be targeted
with pharmaceutical
drugs
• NCBI BLAST searches are
used to analyze
information.
Copyright © 2017 W. W. Norton & Company
Bioinformatics Breakthrough
• Identification of the ICMT mutation observed in
Hutchinson-Gilford progeria
Copyright © 2017 W. W. Norton & Company
Polymorphisms – 1
• Mutations that occur within the genome
• Single nucleotide polymorphisms (SNP)
• One mutation
Copyright © 2017 W. W. Norton & Company
Polymorphisms – 2