Académique Documents
Professionnel Documents
Culture Documents
Daughter
cells
Cleavage
furrow
Anchorage, cell density, and chemical growth
factors affect cell division
The cells within an organism’s body divide and
develop at different rates.
Cell division is influenced externally by
– the presence of essential nutrients,
– growth factors, proteins that stimulate division, there are
over 50 different growth factors which work for one or
more cell type
– density-dependent inhibition, in which crowded cells
stop dividing,
– anchorage dependence, the need for cells to be in
contact with a solid surface to divide.
Growth factors signal the cell cycle control
system
The cell cycle control system is a cycling set of
molecules in the cell that
– triggers and
– coordinates key events in the cell cycle.
Cyclins
proteins produced by the cell during cell division
MPF
Maturation-promoting factor (mitosis promoting factor)
aka Mitosis- promoting factor is a cyclin-Cdk complex
phosphorylates proteins needed for mitosis
needed to go through G2 checkpoint
Rate of Cell Division
• Differs from one cell type to the next
– Examples:
• red bone marrow cells divide every 12 hours to replace RBCs that
wear out
• Cells at tip of root divide about every 19 hours.
• Neurons (nerve cells) normally never divide again once brain is fully
formed in utero
Egg cell
n
Sperm cell
Meiosis Fertilization
Ovary Testis
Diploid
zygote 2n
(2n 46)
Key
Mitosis Haploid stage (n)
Multicellular diploid
adults (2n 46) Diploid stage (2n)
How meiosis halves chromosome number…
Sister
chromatids
1 2 3
A pair of A pair of
homologous duplicated
chromosomes homologous
in a diploid chromosomes
parent cell
MEIOSIS I: Homologous chromosomes separate
INTERPHASE:
Chromosomes duplicate Prophase I Metaphase I Anaphase I
Tetrad
Chromatin Sister Metaphase
Nuclear Centromere
envelope chromatids Fragments (with a plate Homologous
of the kinetochore) chromosomes
nuclear separate
envelope
MEIOSIS II: Sister chromatids separate
Telophase II
Prophase II Metaphase II Anaphase II and Cytokinesis
increases genetic C E
diversity by c e
chromosomes. C E
Chiasma
c e
3 Separation of homologous
chromosomes at anaphase I
C E
C e
c E
c e
Separation of chromatids at
4 anaphase II and
completion of meiosis
C E
Parental type of chromosome
C e
Recombinant chromosome
c E
Recombinant chromosome
c e Parental type of chromosome
Gametes of four genetic types
Independent orientation of chromosomes in
meiosis and random fertilization lead to
varied offspring
Independent orientation at metaphase I