Académique Documents
Professionnel Documents
Culture Documents
Shock
Dr. MUSOFA RUSLI, SpPD
Dept. Ilmu Penyakit Dalam - FKUA
2015
Introduction
Clinical syndrome that results from inadequate
tissue perfusion
Imbalance between the delivery of and
requirements for oxygen and substrate cellular
dysfunction
cellular injury induces the production and
release of damage-associated molecular patterns
(DAMPs or "danger signals") and inflammatory
mediators further compromise perfusion
MOF death
3/6/2014 Pathophysiology: Internal Medicine 2015 2
Shock-induced vicious cycle
Physiologic Tissue
Preload Pump function Afterload
variable perfusion
Hypovolemic ↓ ↓ ↑ ↓
Cardiogenic ↑ ↓ ↑ ↓
Distributive ↓ or ↔ ↑ ↓ ↑