LOPERAMID

IMODIUM® (loperamide hydrochloride), 4-

(p-chlorophenyl)-4-hydroxy-N, N-dimethyla,
a-diphenyl-1-piperidinebutyramide
monohydrochloride, is a synthetic
antidiarrheal for oral use.
 Merupakan analog opioid
berikatan dengan reseptor
opioid pada usus

inhibits the release of

has direct effects on circular acetylcholine and
and longitudinal muscle prostaglandins

reducing peristalsis, and increasing intestinal

transit time
 INDIKASI & DOSIS
Acute • Dosis awal 4 mg (2 tablet) diikuti 1 tablet (2 mg)
setiap selesai buang air besar.
Diarrhea Dosis tidak boleh melebihi 16 mg sehari.

Chronic • Dosis awal 4 mg (2 tablet). Dosis awal harus

disesuaikan sampai 1-2 kali feses keras sehari
yang biasanya dicapai dengan dosis 1-6 tablet
Diarrhea (2mg-12mg) sehari.

Traveler’s • 4mg, tidak melebihi 8mg/hari

Diarrhe
 KONTRAINDIKASI

hipersensitivitas bloody diarrhea high fever

pseudomembranous
infectious diarrhea
colitis
 Kelainan ginjal
,saraf, umum

Kelainan Adverse Kelainan kulit

dan jaringan
gastrointestinal subkutan
effect

Kelainan sistem
imun
 Kategori kehamilan : B

B:May be acceptable. Either animal studies show no risk but human

studies not available or animal studies showed minor risks and human
studies done and showed no risk.

Lactation: Not known if distributed in breast

milk; use caution