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Topical Application of Natural Honey,

Beeswax and Olive Oil Mixture for

Atopic Dermatitis or Psoriasis: Partialy
Controlled, Single Blinded Study

Ersee Hera Gratia
 Psoriasis and atopic dermatitis (AD) represent
challenging problems regarding their management
and incidence.
 Atopic dermatitis is the most common inflammatory
skin disease in childhood
 Treatments include Vaseline, corticosteroids,
cetirizine, antibacterial drugs and phototherapy
 Psoriasis vulgaris (PV) is one of the common-est skin
problems seen by general practitioners
 Psoriasis is a chronic inflammatory and proliferative
disorder of skin that results in a rapid turnover of the
skin cells that move rapidly up to the surface in 3–5
days. This leads to thickening of the su-perficial layers.
 For PV involving less than 20% of body surface area, initial
treatment is topical including emollients (paraffin), keratolytics
(salicylic acid), coal tar, zinc, retinoids, dithranol, betamethazone
and calcipotriene.
 Adverse effects include skin irritation, salicylate intoxication,
unpleasant odor, staining of clothes, thinning of skin, steroid striae,
telangiec-tasia, potential carcinogenic risk and tachyphylaxis with
repeated use of steroids.
 Other treatments such as phototherapy and systemic therapy
(methotrex-ate, cyclosporine, acitretine) are associated with
 Honey reduces inflammation, edema, and exudation,
promotes healing, diminishes scar size, and stimulates
tissue regeneration
 Olive oil, beeswax and honey are natural materials
that contain favonoids, antioxidants, antibacterial in-
gredients and effects cytokines production by skin
cells when applied topically
 The objective of the study is to investigate the
therapeutic effect of honey mixture prepared by
mixing natural honey, beeswax and olive oil on the
skin lesions in patients with AD
Materials and method

 Honey mixture was prepared by thorough mixing of

natural honey, olive oil and beeswax (v/v/v, 1:1:1).
 Honey mixture with corticosteroid ointment was pre-
pared in a v/v ratio of 1:1 (Mixture A), a ratio of 2:1
(Mixture B), and in a ratio of 3:1 (Mixture C)
 Honey was dark yellow in color, multifloral origin, and
its composition included fructose 38%, glucose 28%,
acidity 13%, moisture 20%, Vitamin C 2.3 mg%, copper
0.09 mg%, zinc 0.6%, sucrose less than 0.5 mg%, pH
3.8, and glutathione reduc-tase 0.5 mg%. Natural olive
oil was prepared by cold press.
Study design

 The study was patient-blind partially controlled con-

ducted in two parallel parts among patients referred
to the Dermatology Clinic, Dubai Specialized Med-ical
Center and Medical Research Laboratories.
 The study was approved by Human Ethical
Committee, Islamic Establishment for Education.
Informed con-sent was obtained from the patients or
their parents after thorough explanation of the
Dermatitis Atopik

 21 patient, 4 female and 17 male

 Grup 1, 10 patients
 Grup 2, 11 patients
 At each visit, the body lesions were assessed separately by the
author for signs including ery-thema, scaling, lichenification,
excoriation, indura-tion/papulation, oozing/crusting, and for
the re-ported intensity of pruritis.
 The severity of each sign and symptom was assigned a score of
0–4; none = 0, mild = 1, moderate = 2, severe = 3, and very
severe = 4
Psoriasis vulgaris

 18 patients, 14male and 4 female

 Group 1, 8 patients
 Group 2, 10 patients
 Target lesions were assessed for redness, scaling,
thickening, and itching; each on a 0–4 scale (none = 0,
mild = 1, moderate = 2, severe = 3, and very severe =

 Honey reduces pain, oedema, exudates and scar

formation. Honey seems to accelerate wound heal-ing
as measured by the thickness of granulation tissue,
epithelialisation from the periphery of the wound and
the size of the open wound. Pure honey inhibited
fungal growth and diluted honey appears capable of
inhibiting toxin production.