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NOTES
RABBE ZIDNI ILMA 21 April 2018 2
Rabbe Zidni Ilmaa
System
Autonomic system.
• Autonomic further classified into Enteric,
Sympathetic n Parasympathetic.
• Enteric System is influenced by the Opoids.
2. Cholinergic Antagonist:
Antimuscarinic:
Commonly known as antimuscarinics, these agents block muscarinic receptors, causing inhibition of all muscarinic functions.
Atropine, Scopolamine, Ipratropium.
Ganglionic Bolckers:
Ganglionic blockers specifically act on the nicotinic receptors of both parasympathetic and sympathetic autonomic ganglia.
Except for nicotine, the other drugs mentioned in this category are nondepolarizing, competitive antagonists.
Mecylamine, Nicotine.
Neuromuscular Bolckers:
These neuromuscular blockers are structural analogs of acetylcholine, and they act either as antagonists (nondepolarizing type)
or agonists (depolarizing type) at the receptors on the end plate of the neuromuscular junction. Neuromuscular blockers
are clinically useful during surgery for producing complete muscle relaxation
Atracurium, Doxacurium, Succinylcholine, Tubocurarine.
2. Adrenergic Antagonist:
α-Blockers:
Drugs that block α-adrenoceptors profoundly affect blood pressure.
Doxazocin, Prazocin, Terazocin, Tamsulosin.
Β- Blockers:
All the clinically available B-blockers are competitive antagonists. Nonselective B-blockers act at both B1 and B2
receptors, whereas cardioselective B antagonists primarily block B1 receptors.
Atenolol, Esmolol, Labetalol, Pindolol.
NT Uptake or Release:
Guanethidine, Reserpine.
Nicontine None