CANCER DE

PRÓSTATA
Alumnos :
- Merino Coronado , Raúl André
- Morales Tapia , Michael
Incidencia y mortalidad en
el Perú
 Nacionalidad
Alto consumo
de Calcio
Clasificacion Gleason
Patrones Gleason
“ TODA
GLANDULA
CRIBIFORMES
ES PATRON 4
“
“
“
“
“
 ESTADIFICACION
PRONOSTICA

Gradacion Gleason Invasion Supervivencia

ganglionar a 10 años

2a4 16% 97%

5a7 39% 78%
8 a 10 60% 30%
 Evaluación clínica
 Síntomas Posibilidad de  Obstrucción
Neoplasia
 Síntomas
 Síntomas Irritativos  Síntomas Obstructivos
(50%) (80%)
 Nicturia  Disminución del
 Frecuencia urinaria calibre y fuerza del
flujo urinario
 Urgencia urinaria
 Interrupción del
 Tenesmo vesical
flujo urinario
 Titubeo miccional
 Goteo post-
miccional
Otros signos y síntomas :

 Disuria
 Flujo miccional no cilíndrico
 Dolor en glande
 Disfunción eréctil
 Hematuria
 Dolor suprapúbico
• Lumbalgia
Valoración de la Obstrucción :

 Ultrasonido transabdominal
de vejiga y próstata con
medición de orina residual
post-miccional

 Urografía excretora

 Uroflujometría
 Posibilidad de Neoplasia :

 Tacto rectal
 Antígeno prostático específico
 USG Transrectal de próstata
 Biopsias transrectales
PSA (Variaciones)
Sustancia producida por las células en la
glándula prostática
<4 >10
4-10
ng/ ng/
ng/m
ml ml
◎ La mayoría de los l
hombres sin cáncer ◎ Los hombres que ◎ Si el PSA es
de próstata tiene tienen un nivel de mayor de 10, la
niveles de PSA PSA de 4 a 10 probabilidad de
menores a 4
tienen una tener cáncer de
nanogramos
(ng/mL) por probabilidad de 1 próstata es de
mililitro de sangre. en 4 de padecer más de 50%.
La probabilidad de cáncer de
tener cáncer de próstata.
próstata aumenta a
medida que el nivel
de PSA sube.

◎ 15 % si tienen
cancer , usar
Biopsia.

PSA (Variaciones)
Factores distintos al cancer de
prostata (PSA Aumentado) :
◎ -HPB
◎ -Edad mayor
◎ -Prostatitis
◎ -Eyaculación
◎ -Montar en bicicleta
◎ -Ciertos procedimientos
urológicos (biopsia de
prostata y tacto rectal)
◎ -Ciertos medicamentos
(hormonas masculinas
:testosterona)
◎ Tienen PSA aumentado
aproximadamente el 80% de
los pte con Ca demostrado y
el 30% de los HPB.
Algunas cosas pueden causar
que los niveles de PSA bajen:
◎ -Inhibidores de la 5-alfa
reductasa
◎ -Obesidad
◎ -Aspirina
◎ -Estatinas
◎ -Diureticos tiazidicos
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