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SÍNTESE, CARACTERIZAÇÃO E
APLICAÇÃO EM SISTEMAS
BIOLÓGICOS COM ÊNFASE EM
FÁRMACOS E COSMÉTICOS
The biomass was filtrated and AgNO3 (10 mM) was added
in the fungal liquid
MATERIAIS E MÉTODOS
Culturas de
Fusarium spp
MEV - nanopartículas
Espectro UV-vis Cultura em
meio
0,017/10-3 M de AgNO3
líquido (YM)
72 Horas
12 Horas
Biomassa em
Solução coloidal de reação Caldo fungal água destl.
Para seleção da linhagem com melhor eficiência, levamos em
consideração os dois métodos de biossíntese, tanto usando a
biomassa quanto usando o líquido fungal
A Métodos B
Impregnação em
tecido têxtil para
atividade biocida
Algodão 100% Poliéster
Teste oligodinâmica
48 Horas
sob
agitação
2
5
ATIVIDADE BIOCIDA DO TECIDO IMPREGNADO
(ALGODÃO) COM NANOPARTÍCULAS DE PRATA
frente a bactéria S. aureus
MICROSCOPIA ELETRÔNICA DE VARREDURA DO TRATAMENTO
DE ALGODÃO COM NANOPARTICULAS DE PRATA
Tecido com
nanopartículas de
prata
M.O do Poliéster
impregnado com
nps.
POSSÍVEL RECUPERAÇÃO
E:epidermid
HF: hair follicles
CULTURA DE MICRORGANISMOS NO PANO DA FERIDA NOS DIAS 1, 3, 5, 7 E 10 NOS ANIMAIS
TRATADOS COM ND (GRIS), SSD (BRANCO E NÃO TRATADO (GRIS ESCURO)
silver nanoparticles can modulate local and systemic
inflammatory response following burn injury by cytokine
modulation.
ND VGEF IFN-gama
▄ No treatment
▲ SSD
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Sintese quimica e fungica
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Goal
HAuCl4 + NaBH4
Imã
SEPARAÇÃO
ANALISE
MLDI Analysis: (H. Steen and M. Mann. “The abc’s (and xyz’s) of peptide
sequencing”. Nat. Rev. Mol. Cell Biol. 5, 699-711 (2003)).
Staphylococcus saprophyticus were collected from patients at the Hospital,
Streptococcus pyogenes JRS 75 and JRS 4 were from collections S. pyogenes
JRS 75 was obtained by mutating M protein from the strain of S. pyogenes
JRS 4.29
The lowest cell concentration that was detected for both Staphylococcus
saprophyticus and Staphylococcus aureus in aqueous sample solutions (0.5
mL) was 3 x 10(5) cfu/mL, while the detectable cell concentration for S.
saprophyticus in a urine sample was 3 x 10(7) cfu/mL
Absorption and desorption of chemotherapeutic drugs
from a magnectically targeted carrier (MTC). Rudger et al.
J. Control. Releae 74, 335-340 (2001).
Doxorubicin follows the Langmuir theory for
milling, particles are resuspended and dispersed,
adsorption to MTCs. The Langmuir theory
holds that the solute adsorbs to sites on the carbon
surface in a discrete one to one correspondence.
ACTIVATED CARBON
As shown in the left panel following the treatment of a HCC tumor with MCT-DOX the hepatic arteries
Remain patent, demonstrating particles toletaribility as evidenced by the lack of trombosis and/or
embolization of the arteries. Localization and retention of the particles in the target tumor are showed
in the the righ papel by magnetic resonant imagins (MIR) (the particles were in the local after 28 days)
DOENÇAS
DE PELE
ACNE
Contra a bacteria Propiobacterium acnes
associada em parte com a inflamação do
acne
Clindamycin
Emulsão topica 1% ou gel
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Durán et al. Patente submetida (2007)
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ACNE
AGRADECIMENTOS
REDE NANOTUB0S
DE CARBONO
CNPq/MCT
CNPq/MCT