• Indicate that the lesion is above the anterior horn cell (i.e. spinal cord, brain stem, motor cortex). • Are characterised by increased muscle tone (spasticity), weakness (generally flexors weaker than extensors in the legs and the reverse in the arms - pyramidal pattern of weakness), increased reflexes, an up-going plantar response and sustained clonus (a few beats is normal). • LOWER MOTOR NEURONE SIGNS • Indicate that the lesion is either in the anterior horn cell or distal to the anterior horn cell (i.e. anterior horn cell, root, plexus, peripheral nerve). • Characterised by decreased muscle tone, weakness and wasting (atrophy) in the muscle(s) supplied by that motor nerve, arreflexia (absence of the relevant reflex - the motor nerve is the efferent arm of the reflex arc), muscle fasciculations. Facial Nerve Lesion • Upper motor neuron lesion • Contralateral lower quadrant weakness • Angle of the mouth • Opposite side • Lower motor neuron lesion • Ipsilateral orbicularis oculi muscle and facial muscles involved • Half of face • unable to close eyes • weakness of angle of the mouth • cannot elevate eyebrows • Same side • Examples of UMN: - Cerebrovascular accident • Stroke is the most common - Intracranial tumour - Cervical spine injury - Cerebral Palsy • Examples of LMN: - Motor neuron disease - Peripheral nerve neuropathy - Poliomyelitis anterior horn cell affected - Spinal cord injury with nerve root compression - Guillain-Barré syndrome - C. botulism - Cauda equina syndrome