Diet theory for obesity ,diabetes,heart

disease,and cancer

dr pv satyanarayana
ms; mch; mba
cardio thoracic surgeon
 Main Issues

• Over weight and obesity

• Diabetes

• Cardiovascular diseases

• Cancer

All these problems influenced by Diet

 The Conventional Wisdom

• The fundamental cause of obesity and

over weight is energy imbalance
between calories consumed and calories
expended

The world health organization

More than 40in in men
More than 35in in women
Obesity is energy
imbalance
disorder
Calorie is Calorie
99.2% failure in 2 years
 Fat storage
• Insulin not only shuttles glucose into the cells, but also
triggers the conversion of glucose into fatty acids and
shuttles them into the fat cells.

• Insulin is a fat storage hormone.

• The more insulin you have coursing through your

bloodstream, the more fat is deposited in your fat cells.

• When blood insulin levels are high, your body stores fat
and you gain weight.
 fats

• Eating fat and protein have very

little effect on blood glucose levels
and therefore, do not stimulate
much of an insulin response, and
do not encourage fat storage.
Calorie is not Calorie
September 24th 1955
5 Ways to burn 100 calories

1) Walking 45 minutes

2) Jogging 16 minutes

3) Swimming 17 minutes

4) Climbing stairs 16 minutes

5) Tennis 15 minutes
One extra bite increase 20 calories
20 calories day in 10 years increases 8KG weight
 diet composition
carbs
5 to10%

Protein 20 to 30%

FATS 60 to 75%

Low Carbohydrate High Fat diet

(LCHF)
 Statistical Data

Variable Sample mean SD SE 95% CI P value

size

Reduction in 101 7.03 4.31 0.428 6.19 to 7.87 <0.0001

weight in kg

Reduction in BMI 101 2.80 1.60 0.159 2.49 to 3.11 <0.0001

 Confidence intervals
10.00

Weight reduction
8.00
7

6.00

4.00
3
BMI Reduction
2.00

0.00
0 1 1 2 2 3
Diabetes type II
Diabetics in the world
1917 book
GI index
Dangerous enemy of
modern world
Rava dosa Upma Made Out of Suji
(Semolina which is derived from wheat
Pancake)- a South
Indian dish or
breakfast, made
with Bombay rava
Cauliflower Rice Upma or Biryani
coconut flour or almond flour bread
Avocado

Omega 3
fatty acids
omega 3 fatty acids
o
Chia Seeds
Paneer
Heart diseases
 Indian Statistics about CVD

• Current projects suggest that by the year 2020,

India will have largest cardiovascular burden in the
world.

• 1/5 of deaths India are due to coronary vascular

disease. By 2020 it will account for 1/3 deaths.

• Majority of them are likely to be Young Indians.

Farming ham study
 low fat calorie restricted diet
(Eat Less & Move More)

• Women's health Initiative RCT study

(50 thousand women over 7 year period)

• one group followed low fat high carbohydrates with fruits and
exercise routines with calorie restriction

• Other group eat what they want and no compulsory exercise.

• At the end difference between two groups is less than 2 pounds

• Waist size increased from 35 to 35.4 in low fat group

• All cause mortality was high in LOW FAT group

23 Studies on Low-Carb and Hi
Shai I, et al. Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet. The N
Foster GD, et al. A randomized trial of a low-carbohydrate diet for obesity. New England J
Fructose
metabolism
better under
stood
Sweden reduced its heart attacks after
butter
10000 years only
Refined proceeded carbohydrate food
80% fat
20% proteins
0% carbohydrates
Essential Amino Acids
 Do Humans Need to eat Carbohydrates ?

• The lower limit of dietary carbohydrates compatible with life

apparently is “ZERO”.

The minimal amount of exogenous and endogenous carbs is

dependent upon the brain( 100 - 140 grams of glucose /day).

• After kept adaptation, about 80 % of CNS energy can be derived from

ketones, leaving 20-28 grams glucose / day.

• Endogenous Glucose production rate 2-2.5 mg/kg/day =2.8 to 3.6

Grams / day.

• In a 70 kg man this represents 210 - 270 grams / day.

Institute of Medical dietary performance intake 2008

Eat Healthy Fats To loose Fat
Microbes
and
we
Why we should care about our gut biome ?
 gut bacteria

obesity
Medium chain
fatty acids

Virgin
Cold
pressed
Coconut
Oil
cancer
Cancer Frequency

• In 1900 1 in 20

• In 1940 1 In 16

• In 1970 1 in 10

• in 2016 1 in 3
 cancer

• Cancer is it nuclear
genetic disease or
mitochondrial metabolic
disease ?
FDG, which stands for “fluorodeoxyglucose”.
Angelina Jolie
“fluorodeoxyglucose”.
• Sugaraddiction
is the Achilles
heel of cancer
cells
80% fat
20% proteins
0% carbohydrates
లంకణం పరమ ఔషధం
ఆయురేవేద
చరక సంహిత
 Ancient to modern times

Ancient physicians believed in value of physical activity to

health

• Yoga & Surya namaskaras 5000 years

• China 4000 years
• Hippocrates 2400 years
• Since industrial revolution
• Reduction in physical activity at work
• Early 20th century
• Complete bed rest for MI
 Early 20th century

Physical endurance by exercise

• Peter Coe 1970
• ArthurJones 1970
• Tabata 1996
• Doug Mcguff 2009
• Gibala 2011
• Land mark series in Lancet July 2012
fasting a form disagreement and resolving conflicts
children get their job
 insulin Boon or Bane
• Insulin protects us from starvation by adding some
fat to the body during feast time.

• Lack of Insulin mobilises the stored fat from fat

sources and sustain life till we get fresh food again.
Trouble shooting

Re boot
Fasting benefits
Die “Young” as
Late as possible
1968, Dr. Kenneth H. Cooper's best-
selling book, Aerobics, was hailed by
Newsweek as "the Bible of the
fitness movement."
The man who saved americas hearts
The man who destroyed americas knees
Yoga and AIS involves all
types of muscle fibres
40 Year athlete

74 yr old sedentary

70 year old athlete

 High Intensity Interval
Training

(HIIT)

4 minutes a day
and 12 minutes in
a week
 1.Eat fat to reduce fat

2. Fitness of body improves

in kitchen
rather than in Gym
 Acknowledgements
• Gary Taubes
• Tim Noakes
• Eric Westman
• Robert Lustig
• Gary Fittek
• Jeff Volek
• Stephen Phinney
• Jason Fung
• And many others