JOURNAL READING

Effects of intratympanic dexamethasone on noise-induced

hearing loss:
An experimental study

By:
Fajar Baskoro
012116388
IDENTITAS JURNAL
Judul :Effects of intratympanic
dexamethasone on noise-induced
hearing loss: An experimental study
Pengarang : Sait Serdar Gumrukcu , İlhan
Topaloglu , Ziya Salturk , Belgin Tutar , Yavuz
Atar , Güler Berkiten c , Ayşe Enise Göker
Kırklareli Government Hospital, Turkey
Yeditepe University Faculty of Medicine, ENT
Clinic, Turkey
Okmeydanı Training and Research Hospital,
ENT Clinic, Turkey
Surgery 39 (2018) 71
Otolaryngology–Head and Neck Medicine and
Publish https: American Journal of
 Latar
belakang

Kesimpula ABSTRA Metode

dan
n
K materi

Hasil
INTRODUCTION

Therapy of steroid/dexamethasone
intratimpany and its effect not clearly
explained

Aim of the study was to evaluate the

effect of intratympanic steroid treatment
on hearing based on otoacousticemission.
METHOD

Terdapat 16 tikus galur wistar

dalam penelitian ini

Di bagi 2 kelompok, tiap kelompok

terpapar bunyi 110dB selama 25
menit
Dexamethason di berikan
intratimpani pada kelompok
perlakuan
kelompok control di berikan cairan
normal salin, pengukuran hari ke
7 dan 10
RESULT
There were no differences
between the emission
results of two groups before
treatment

There were significant

group differences on
measurement days 7 and
10 at all frequencies.
CONCLUSION
Our study revealed a significant difference in
DPOAE measurements on days 7 and 10
between the
experimental and control groups.We detected
a positive effect of dexamethasone on noise-
induced hearing loss.
INTRODUCTION
Acoustic trauma is characterized by noise-
induced loss, deformation of the outer hair
cells of the cochlea, and a disturbance in
cochlear microcirculation

The main goal in the treatment of acoustic

trauma is to reestablish cochlear
microcirculation and provide sufficient
oxygenation
 we evaluated the effect of intratympanic
steroid treatment on hearing based on oto-
acoustic emission
METHOD
 Before
This study was performed measurement of
at the Animal Research OAE was
Laboratory of Istanbul
administered
University, Faculty of
Medicine 45mg/kg ketamin
and 5 mg/kg
xylazin
A total of 16 8 rats
healthy female experimental
Wistar albino rats group exposed to
noise at
8 rats control 110 dB
November 2011 group
 Injected
insulin and
injected Measurement of
8 rats dexametas OAE by otoscop
experimental on 1cm 3 on days 7 and 10
group and
measurement of
Injected DPOAE by ILOv5
8 rats control normal device
group saline
0,09%
RESULT
 Steroid P Saline solution p
Mean ± SD Median Mean ± SD Median
4004 Hz
Sebelum terapi 31,01 ± 33,65 29,60 ± 31,10 0,674
5,31 7,60
Hari ke-7 terapi 7,99 ± 0,19 8,05 26,26 ± 25,40 0,001*
5,36
Hari ke-10 terapi 7,32 ± 0,42 7,40 21,45 ± 21,50 0,001*
1,32
4761 Hz
Sebeum terapi 37,12 ± 36,50 33,67 ± 33,55 0,141
3,23 5,17
Hari ke-7 terapi 18,23 ± 18,55 34,51 ± 35,45 0,001*
1,04 4,80
Hari ke-10 terapi 17,15 ± 17,25 38,60 ± 38,65 0,001*
0,64 0,82
5652 Hz
Sebelum terapi 44,92 ± 43,10 41,29 ± 43,70 0,600
5,52 6,61
Hari ke-7 terapi 20,71 ± 20,30 43,78 ± 44,25 0,001*
1,29 5,76
Hari ke-10 terapi 20,69 ± 21,05 39,77 ± 40,20 0,001*
0,84 0,89
6726 Hz
Sebelum terapi 32,09 ± 29,90 32,06 ± 32,25 0,834
7,52 5,54
Hari ke-7 terapi 21,70 ± 21,85 34,84 ± 36,50 0,001*
0,57 4,95
Hari ke-10 terapi 20,45 ± 20,65 36,63 ± 37,00 0,001*
0,87 0,62
7996 Hz
Sebelum terapi 38,25 ± 39,30 37,01 ± 35,80 0,674
4,67 3,85
Hari ke-7 terapi 23,92 ± 23,50 38,79 ± 40,15 0,001*
0,96 4,17
Hari ke-10 terapi 22,70 ± 23,50 40,55 ± 40,80 0,001*
1,35 0,81
 DISCUSSION
Mechanical trauma and biochemical damage are
believed to be responsible for acoustic trauma.
Noise-induced hearing loss causes high-frequency
sensorineural hearing loss

Intratympanic steroids are used commonly to treat

inner ear diseases. However, the effect of steroids
on the inner ear remain unclear. It has been shown
that topical application of dexamethasone on the
round window results in diffusion into the perilymph.
Intratympanic menghasilkan konsentrasi steroid
yang lebih tinggi di telinga bagian dalam
dibandingkan dengan intravena intraperitoneal,
meskipun steroid dapat melewati seluruh sawar
darah otak
KESIMPULAN
Terdapat perbedaan signifikan dalam
pengukuran DPOAE hari ke 7 dan 10 pada
ke dua kelompok
Terdapat efek positif dexametason pada
gangguan pendengaran
TERIMA KASIH