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Human Cytomegalovirus

Human Cytomegalovirus Infection in Stillbirths and the Fetal Thrombotic Vasculopathy

Infection in Stillbirths and the Fetal Thrombotic Vasculopathy

Human Cytomegalovirus Infection in Stillbirths and the Fetal Thrombotic Vasculopathy

Infectious Diseases

2011
2011

Maria E. Craig Jenna M. Iwasenko Jonathan Howard Susan Arbuckle Nicole Graf Beverley Hall William D. Rawlinson

Figure 1 . CMV protein in fetal organs and placentae from stillborn infants . Representative fetal

Figure 1. CMV protein in fetal organs and placentae from stillborn infants. Representative fetal sections were brown in the presence of anti-CMV antibody (left), no staining in the absence of primary anti-CMV antibody (middle) and H&E (right). (Original magnification, 3400.)

Figure 2 . Microscopic characteristics of histopathological conditions observed at autopsy . A, Chorioamnionitis showing neutrophil
Figure 2 . Microscopic characteristics of histopathological conditions observed at autopsy . A, Chorioamnionitis showing neutrophil

Figure 2. Microscopic characteristics of histopathological conditions observed at autopsy. A, Chorioamnionitis showing neutrophil infiltration (hematoxylin-eosin staining; original magnification, 310).

Figure 2 . Microscopic characteristics of histopathological conditions observed at autopsy . A, Chorioamnionitis showing neutrophil

B, Fetal thrombotic vasculopathy as characterized by vascular karyorrhexis in the villous stroma caused by degeneration of the

capillaries and the presence of karyorrhectic cell debris (arrow) in the lumen and stroma of the villi [24] (hematoxylin-eosin staining; original magnification, 320). C, Placental infarct from maternal underperfusion with increased perivillous fibrin (hematoxylin-eosin staining; original magnification, 320). D, Villitis with cluster of aggregated villi (hematoxylin-eosin staining; original magnification, 320).

Figure 2 . Microscopic characteristics of histopathological conditions observed at autopsy . A, Chorioamnionitis showing neutrophil
Figure 2 . Microscopic characteristics of histopathological conditions observed at autopsy . A, Chorioamnionitis showing neutrophil
Table 4. Findings from Clinical and Placental Histological Examination of Between Cytomegalovirus (CMV) – Infected and

Table 4. Findings from Clinical and Placental Histological Examination of Between Cytomegalovirus (CMV)Infected and CMVUninfected Stillborn Infants

No. (%) of cases

Pathological finding

CMV positive(n-20)

CMV-uninfected(n-89)

Clinical appearance

IUGR

 

7 (35)

44 (46)

P 5.179

Fetal hydrops Amniotic fluid infection:

3 (15)

17 (18)

P 5.571

Chorioamnionitis

5 (25)

18 (19)

P 5.207

Decidual change

 

Deciduitis

3 (15)

12 (13)

P 5.496

Decidual vasculopathy

 

6 (30)

22 (23)

P 5.367

Maternal underperfusion, ischemia, and infarction

12 (60)

48 (50)

P 5.406

Villous inflammation

 

Villitis

4 (20)

10 (10)

P 5.192

Histiocyotic intervillositisd Fetal vascular change:

1 (5)

1 (1)

P 5.335

fetal thrombotic vasculopathy

12 (60)

27 (28)

P 5.010