Angioleiomyoma

Deba P Sarma, MD Omaha

M 61, right 5th finger mass

SMA: Positive

Comment
The encapsulated soft tissue tumor is composed of numerous thick-walled and thin-walled vessels with thickthinperivascular pink spindle cell proliferation. There is no increased mitosis, atypical mitosis or necrosis. The spindle cells are strongly positive for smooth muscle actin (SMA) suggesting leiomyomatous nature of the tumor arising from the vessel walls.

- Solitary subcutaneous or dermal painful tumor of

extremities and head. - More common in women. Pathologic findings: - Well circumscribed nodules composed of smooth muscle. - Smooth muscle cells of the tumor merges to the smooth muscle walls of vessels with with varying degree of patency. - Smooth muscle markers are positive. - Differential diagnosis: Dermatofibroma, neurofibroma, dermatomyofibroma