AIDS

By/ Mohamed I.Taha

 What is difference between
HIV and AIDS ?
HIV is a Human Immunodeficiency Virus
AIDS is Acquired Immune Deficiency Syndrome
( Syndrome which appears in advanced stages of HIV infection )
 Virology
 HIV infection → AIDS

 HIV → Immune System → CD4+ T cells → Destruction

 Single-stranded RNA → Target Cell → Double-Stranded DNA →

new virus particles → Replication Cycle
 Types of HIV

HIV-1 HIV-2
( LAV or HTLV- III ) Poor Capacity for
Transmission
More COMMON
West Africa
More Infective

More Virulent
Signs and Symptoms

AIDS

Clinical Latency

Acute Infection
 Acute Infection
(Acute HIV, Primary HIV, Acute Retroviral Syndrome)

Symptomatic
Asymptomatic
(40-90%)

Non Specific
( 3-20 Years )
Clinical Latency
(Asymptomatic HIV, Chronic HIV)

First • Few or No Symptoms

Last
• Fever, Weight Loss, GIT
Problems, Myalgia, Generalized
Lymphadenopathy
 Absence of Specific

AIDS
Treatment

(Acquired Immune Deficiency Syndrome)

CD4+ T cell Count Below 200 cells/micro liter

OR

Occurrence of Specific Diseases in Association with HIV Infection

Additionally……..

Kaposi’s Sarcoma

Burkitt’s Lymphoma

Primary CNS Lymphoma

Cervical Cancer

Conjunctival Cancer

Opportunistic Infections
Transmission

Sexual

Body Fluids

Mother to Child
 Sexual

Commercial
Homosexual Heterosexual Sex Workers
(Pornography)

Rough Sex Sexual Assault

Body Fluids

Blood
and
Blood Products
Mother to Child

Feeding

Delivery

Pregnancy
 Diagnosis

Lab.Testing Staging

PCR

HIV RNA or DNA

P24 Antigen

Antibody tests in children younger than 18 months are typically

inaccurate due to the continued presence of maternal antibodies.
 Classifications

WHO CDC

WHO: World Health Organization

CDC: The United States Center for Disease Control and Prevention
 WHO
does not require
laboratory tests

Primary HIV • May be either asymptomatic or associated with acute retroviral

infection syndrome.

• HIV infection is asymptomatic with a CD4+ T cell count (also known

Stage I as CD4 count) >500 per microlitre (µl or cubic mm) of blood. May
include generalized lymph node enlargement.

• Mild symptoms which may include minor mucocutaneous

Stage II manifestations and recurrent upper respiratory tract infections. A
CD4 count of < 500/µl.

• Advanced symptoms which may include unexplained chronic

Stage III diarrhea for longer than a month, severe bacterial infections
including tuberculosis of the lung, and a CD4 count of < 350/µl.

• severe symptoms which include toxoplasmosis of the brain,

Stage IV or AIDS candidiasis of the esophagus, trachea, bronchi or lungs and
Kaposi's sarcoma. A CD4 count of < 200/µl.
 CDC
more frequently
adopted

Stage 0 • the time between a negative or indeterminate HIV

test followed less than 180 days by a positive test

Stage 1 • CD4 count ≥ 500 cells/µl and no AIDS defining

conditions

Stage 2 • CD4 count 200 to 500 cells/µl and no AIDS defining

conditions

Stage 3 • CD4 count ≤ 200 cells/µl or AIDS defining

conditions

Unknown • if insufficient information is available to make any

of the above classifications

For surveillance purposes, the AIDS diagnosis still stands even if,
after treatment, the CD4+ T cell count rises to above 200 per µL of
blood or other AIDS-defining illnesses are cured.
 Prevention
Sexual contact

Pre-exposure

Post-exposure

Mother-to-child

Vaccination
 Sexual contact

Condom Circumcision

Comprehensive
Vaginal Gel
Sexual
(Tenofovir) Education

Spermicide
nonoxynol-9
 Pre-exposure
• among people with HIV whose CD4 count ≤ 550 cells/µL is a
Antiretroviral very effective way to prevent HIV infection of their partner (a
strategy known as treatment as prevention, or TASP).

Pre-exposure
prophylaxis • tenofovir, with or without emtricitabine
(PrEP)

Universal • effective in decreasing the risk of HIV

precautions

Intravenous drug • needle-exchange programs and

use opioid substitution therapy
 Post-exposure

Post-exposure Prevention
Antiretrovirals Prophylaxis zidovudine Regimen
(PEP) (USA)

Tenofovir,
emtricitabine
and raltegravir
 Mother-to-Child

Antiviral Avoid
Medications Breastfeeding
 Vaccination

No licensed vaccine

RV 144

*RV 144 trial to date

Currently
NO Cure Treatment

Preventive
Highly Active Antiretroviral
and
Therapy (HAART)
Active Treatment

treatment of
Slows progression of
the disease opportunistic
infections
Antiviral Therapy
 Antiviral Therapy

Protease Inhibitors
HAART (PI)

if the other regimen

loses effectiveness
NNRTI NRTIs

zidovudine

tenofovir NNRTI: non-nucleoside reverse transcriptase inhibitor.

lamivudine NRTIs: nucleoside analog reverse transcriptase

inhibitors.
emtricitabine
 Notes Antiviral Therapy
Recommended in people of all ages including pregnant women

Once treatment is begun it is recommended that it is continued without

breaks or "holidays"

Benefits of treatment include a decreased risk of progression to AIDS and a

decreased risk of death also improves physical and mental health.

Common side effects: lipodystrophy syndrome, dyslipidemia, and diabetes

mellitus, especially with protease inhibitors. Other common symptoms
diarrhea, an increased risk of cardiovascular disease.
 Society and culture

Religion
Economic
Stigma impact
and
AIDS

Media Criminal
Misconceptions
portrayal transmission
 Stigma

Ryan White became a poster child for

HIV after being expelled from school
because he was infected
 Economic impact

Changes in life expectancy in some

African countries, 1960–2012
 Religion and AIDS
ً ‫س ِّب‬
‫يل‬ َ ‫احشَةً َو‬
َ ‫سا َء‬ ِّ َ‫َان ف‬ ِّ ‫َو ََل ت َ ْق َربُوا‬
َ ‫الزنَا ۖ ِّإنَّهُ ك‬

(Nor come nigh to adultery: for it is a shameful (deed)

and an evil, opening the road (to other evils))

Al-Israa(32)
 Media portrayal

Rock Hudson, a gay actor who had been married and

divorced earlier in life, who died on October 2, 1985
having announced that he was suffering from the virus
on July 25 that year. He had been diagnosed during
1984.
 Criminal Transmission

intentional or reckless infection

of a person with the human
immunodeficiency virus (HIV).
Some countries or jurisdictions,
including some areas of the
United States, have laws that
criminalize HIV transmission or
exposure. Others may charge the
accused under laws enacted
before the HIV pandemic
 Misconceptions
1) AIDS can spread through casual contact

2) sexual intercourse with a virgin will cure AIDS

3) HIV can infect only gay men and drug users

4) one could get HIV from kissing (16%), sharing a glass (5%),
spitting (16%), a public toilet seat (4%), and coughing or
sneezing (5%)
Thank You