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1. Water balance
Osmoreceptor (hypothalamus)
ADH, Vasopressin (Pituitary)
Collecting duct
Absorption of H2O
2. Acid-base balance
Carbonic anhydrase (Distal tubules)
H+ excretion
Na+ reabsorption
H2O excretion
3. Excretion sisa metabolisme
- Acid - base - H2O
- creatinine
- Metabolites
4. Blood pressure : Renin
5. Hematology - erythropoeitin
Stadium gagal ginjal
1. Asymptomatic urinary abnormalities:
GFR > 90 ml/min (> 1,5 ml/s)
disease
DM
Causes
Aminoglycoside nephrotoxicity IV contrast medium Long term use of NSAIDS
(Gentamycin, Azithromycin)
Lab Tests
Ureum ↑ (Normal : 7 to 20 mg/dl )
Electrolyte ( K+ ↑, Na+ ↓)
Urinalysis
CRF: Monitoring Renal Function
Rumus Cockroft & Gault :
Cr Cl.= (140- umur) × BB /Cr P
J Winterbottom 2005
Stadium gagal ginjal
1. Asymptomatic urinary abnormalities:
GFR > 90 ml/min (> 1,5 ml/s)
Peritoneal Hemodialysis
Hemodialysis
Peritoneal